Edaravone is a candidate agent for spinal muscular atrophy: in vitro analysis using a human induced pluripotent stem cells-derived disease model.

In this study, we suggest that oxidative stress might be partly the reason for selective apoptosis in spinal motor neurons in SMA pathology, and that oxidative stress-induced apoptosis might be the therapeutic target of SMA.
PMID: 28826912 [PubMed - as supplied by publisher]

Source: European Journal of Pharmacology - August 18, 2017 Category: Drugs & Pharmacology Authors: Ando S, Funato M, Ohuchi K, Kameyama T, Inagaki S, Seki J, Kawase C, Tsuruma K, Shimazawa M, Kaneko H, Hara H Tags: Eur J Pharmacol Source Type: research