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Establishment of a murine pancreatic cancer pain model and microarray analysis of pain ‑associated genes in the spinal cord dorsal horn.

In conclusion, the present study has developed a novel animal model of pancreatic cancer pain in BALB/c‑nu mice that resembles human pancreatic cancer pain, and the expression of pain‑associated genes in the spinal cord dorsal horn has been profiled. The results of the present study may further the understanding of the molecular mechanisms that mediate pancreatic cancer pain. PMID: 28791352 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research

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[Image from unsplash.com]From Novarad touting its VR-surgical guidance system to Zynex paying off its $2.2M loan, here are seven medtech stories we missed this week but thought were still worth mentioning. 1. Stimwave announces first patient in Brazil Stimwave announced in a July 5 press release that its first patients in Brazil have received Stimwave’s wireless pain relief device treatment for chronic pain. The patients are expected to receive the neuromodulation treatment as an alternative to opioid pain relief. The devices created by Stimwave deliver small pulses of energy to specific nerves to trigger a reac...
Source: Mass Device - Category: Medical Devices Authors: Tags: Clinical Trials Diabetes Diagnostics Imaging Neuromodulation/Neurostimulation Pain Management Research & Development American Red Cross Nemaura Medical Novarad Owlstone Medical Stimwave Tactical Medical Zynex Inc. Source Type: news
Sporadic pancreatic cancer amounts to ∼90% of all pancreatic cancers. It is a gloomy depressive disease and the most recalcitrant malignancy, with a very low 5-year survival (3–6%). At present, diagnostic methods are commonly applied, as used half a century ago, after the appearance of local and systemic symptoms (abdominal and back pain, cholestasis, painless jaundice, fatigue, anorexia, weight loss, anemia, peripheral phlebitis, and cachexia). Unfortunately, these symptoms are harbingers of an advanced disease. The subsequent imaging methods may offer additional information on the location, size, and morphology...
Source: European Journal of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Review Articles Source Type: research
Americans consume the equivalent of 300 loaves of bread each year (representing enormous exposure to the amylopectin A carbohydrate that behaves like sugar or worse). They also consume 200 pounds of sugar. It is not uncommon for sugar alone to comprise a quarter of all calories taken in over the course of the day—some of it out in the open, some of it hidden. To understand the adverse effects of sugars—sucrose, high-fructose corn syrup, and other fructose-rich sweeteners, such as agave, honey, and maple syrup—we need to understand two phenomena: 1. Insulin resistance 2 Glycation. Insulin Resistance When ...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Sugar Undoctored Wheat Belly Lifestyle anti-aging blood sugar diabetes grain-free grains health insulin joint pain Weight Loss Wheat Belly Total Health Source Type: blogs
  Americans consume the equivalent of 300 loaves of bread each year (representing enormous exposure to the amylopectin A carbohydrate that behaves like sugar or worse). They also consume 200 pounds of sugar. It is not uncommon for sugar alone to comprise a quarter of all calories taken in over the course of the day—some of it out in the open, some of it hidden. To understand the adverse effects of sugars—sucrose, high-fructose corn syrup, and other fructose-rich sweeteners, such as agave, honey, and maple syrup—we need to understand two phenomena: 1. Insulin resistance 2 Glycation. Insulin Resistanc...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Sugar Undoctored Wheat Belly Lifestyle anti-aging blood sugar diabetes grain-free grains health insulin joint pain Weight Loss Wheat Belly Total Health Source Type: blogs
CONCLUSIONS: Endosonography guided celiac plexus neurolysis also might be complicated with paraplegia as already observed with percutaneous approach. The underlying mechanism could not be explained clearly until now. We detected concomitant embolic occlusion of Adamkiewicz and anterior radicularis magna arteries in magnetic resonance angiography. So, this procedure must be considered only for malignancy patients. PMID: 28625083 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
The drug sends a message to a caregiver after the patient swallowed it. The doctor prescribes virtual reality treatments for migraines. Do you think it is science fiction? You are mistaken. Just let me familiarize you with the top 10 trends shaping the future of pharma. I gave a speech recently to an audience of professionals working in healthcare regulation for the invitation of the Consumer Healthcare Products Association in Washington. After the keynote, a guy raised his hand and asked me the following: how can a regulatory agency keep up with the speed of new technologies in pharma? I get a lot of questions like this o...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine Future of Pharma 3d printing artificial intelligence augmented reality digital health gc4 Innovation nanotechnology Personalized medicine pharmacies pharmacogenetics pharmacology virtual reality VR Source Type: blogs
PANCREATIC cancer can cause symptoms including jaundice, itchy skin, indigestion, pain in the back or stomach and weight loss.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
In this study we demonstrate the use of clustered regularly interspaced short palindromic repeats (CRISPR)-based epigenome editing to alter cell response to inflammatory environments by repressing inflammatory cytokine cell receptors, specifically TNFR1 and IL1R1. This has applications for many inflammatory-driven diseases. It could be applied for arthritis or to therapeutic cells that are being delivered to inflammatory environments that need to be protected from inflammation." In chronic back pain, for example, slipped or herniated discs are a result of damaged tissue when inflammation causes cells to create ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Welcome to the Medsider interview series, a regular feature at MassDevice. All interviews are conducted by Scott Nelson, Founder of Medsider and Group Director for WCG. We hope you enjoy them! Dr. Bob Smouse has over 20 years of experience in interventional radiology, endovascular surgery and clinical research. In addition to acting as CEO and CMO of BrightWater Medical and teaching at the University of Illinois College of Medicine, he provides interventional medical services to local hospitals through Central Illinois Radiology Associates. Dr. Smouse is a medical consultant and scientific advisory board mem...
Source: Mass Device - Category: Medical Equipment Authors: Tags: Blog medsider Smouse Source Type: news
Conclusion Palliative surgery improves quality of life in recurrent pancreatic cancer patients and can continue patient’s palliative management. In selected patients, palliative surgery may effective management for progress of survival and quality of life.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
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