Differentiating HIV-Associated Neurocognitive Disorders From Alzheimer ’s Disease: an Emerging Issue in Geriatric NeuroHIV

AbstractPurpose of ReviewThe purpose of this review was to examine characteristics that may distinguish HIV-associated neurocognitive disorder (HAND) from early Alzheimer ’s disease (AD).Recent FindingsCerebrospinal fluid (CSF) AD biomarkers are perturbed in HIV, yet these alterations may be limited to settings of advanced dementia or unsuppressed plasma HIV RNA. Neuropsychological testing will require extensive batteries to maximize utility. Structural imaging is limited for early AD detection in the setting of HIV, but proper studies are absent. While positron-emission tomography (PET) amyloid imaging has altered the landscape of differential diagnosis for age-associated neurodegenerative disorders, costs are prohibitive.SummaryRisk for delayed AD diagnosis in the aging HIV-infected population is now among the most pressing issues in geriatric neuroHIV. While clinical, imaging, and biomarker characterizations of AD are extensively defined, fewer data define characteristics of HIV-associated neurocognitive disorder in the setting of suppressed plasma HIV RNA. Data needed to inform the phenotype of AD in the setting of HIV are equally few.
Source: Current HIV/AIDS Reports - Category: Infectious Diseases Source Type: research

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Conclusion: These data suggest that ART exposure is associated with increased levels of Aβ1–42 and Aβ1–40 in the CSF. Also, HAD, but not ANI/MND diagnosis is associated with decreased levels of Aβ1–42 and Aβ1–40 in CSF, potentially suggesting impaired clearance. These data suggest that HIV infection and ART may impact pathogenic mechanisms involving Aβ1–42 and Aβ1–40, but not p-tau.
Source: AIDS - Category: Infectious Diseases Tags: BASIC SCIENCE: CONCISE COMMUNICATION Source Type: research
This study delves into the mechanisms by which a short period of fasting can accelerate wound healing. Fasting triggers many of the same cellular stress responses, such as upregulated autophagy, as occur during the practice of calorie restriction. It isn't exactly the same, however, so it is always worth asking whether any specific biochemistry observed in either case does in fact occur in both situations. In particular, the period of refeeding following fasting appears to have beneficial effects that are distinct from those that occur while food is restricted. Multiple forms of therapeutic fasting have been repor...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusions: The findings suggest that people with Alzheimer's dementia and their caregivers regard mobility aid use as increasing independence. There is a role for healthcare professionals to be involved in the prescription, provision and training for use of mobility aids among people living with dementia to ensure uptake and safety.IMPLICATIONS FOR REHABILITATIONMobility aid use is regarded as increasing independence by people with Alzheimer's disease and their caregivers.Falls risk associated with mobility aid use was not well known and caregivers perceived mobility aids as a means to reduce falls.Most people do not see...
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Tags: Disabil Rehabil Source Type: research
Men and women who had been widowed and who had elevated beta-amyloid levels...Read more on AuntMinnie.comRelated Reading: Amyloid-PET advocates take their case to Congress PET shows tau better predicts brain atrophy than amyloid PET, MRI show physical activity aids brain health PET's view of tau could explain women's early dementia
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Research suggests that paying more attention to the “invisible disability” of hearing loss might improve our brains.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Ears and Hearing Alzheimer ' s Disease Dementia Hearing Aids Brain Source Type: news
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSIONS: Use of HAs is associated with delayed diagnosis of AD, dementia, depression, anxiety, and injurious falls among older adults with HL. Although we have shown an association between use of HAs and reduced risk of physical and mental decline, randomized trials are needed to determine whether, and to what extent, the relationship is causal. The Study in Context: Hearing aids, by reducing cognitive load, can improve brain function in persons with hearing loss 46.7 million Americans have Alzheimer’s Disease brain pathology today, so it’s urgent to prevent or at least delay progression to clinical disea...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Technology anxiety dementia depression fall-related injuries hearing aid hearing loss Medicare older-adults Source Type: blogs
PET/MRI scans show middle-aged adults with high vascular risk factors have...Read more on AuntMinnie.comRelated Reading: PET, MRI show physical activity aids brain health SNMMI: Cerebrovascular risk tied to Alzheimer's disease MRI ties high blood pressure to dementia risk PET links amyloid, vascular factors to cognitive decline PET links midlife vascular risk factors to more amyloid
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
DISCUSSION: In the future, managers and employees in acute care hospitals will be able to find a wide range of suggestions in comprehensive guidelines from the iso-Institute on the modular implementation of dementia-sensitive hospitals, which is backed up by tried and tested and effective aids to action, instruments, process descriptions, etc. The guidelines will also be available in the form of a comprehensive list of recommendations. PMID: 31628614 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Gerontologie und Geriatrie - Category: Geriatrics Authors: Tags: Z Gerontol Geriatr Source Type: research
Brain maps based on functional MRI (fMRI) scans are proving useful in predicting...Read more on AuntMinnie.comRelated Reading: Can MRI of healthy brains explain head trauma damage? Advanced MRI technique confirms dementia risk PET, MRI show physical activity aids brain health MRI links brain region to dementia, auditory deterioration DTI-MRI offers window into Alzheimer's risk
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
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