Systemic Treatment for Squamous Cell Carcinoma of the Head and Neck
In patients with locally advanced squamous cell cancer of the head and neck, a multimodality treatment approach is recommended. The addition of platinum-based systemic therapy concurrently with radiation has been shown to be superior to radiation alone and is considered standard therapy for locally advanced disease. No study has shown superiority of induction therapy followed by chemoradiotherapy versus chemoradiotherapy alone. In the adjuvant setting only patients with nodal extracapsular extension or positive margins seem to benefit from chemoradiotherapy versus radiotherapy alone. In the recurrent or metastatic setting, systemic treatment with chemotherapy is palliative. A subset of patients treated with PD-1 immunotherapy may achieve durable responses.
Source: Otolaryngologic clinics of North America - Category: ENT & OMF Authors: Aditya V. Shetty, Deborah J. Wong Source Type: research
More News: Cancer | Cancer & Oncology | Carcinoma | Chemotherapy | ENT & OMF | Head and Neck Cancer | Immunotherapy | Palliative | Skin Cancer | Squamous Cell Carcinoma | Study