Metabolomic analysis of Entamoeba: applications and implications.

Metabolomic analysis of Entamoeba: applications and implications.
Curr Opin Microbiol. 2014 Jun 17;20C:118-124
Authors: Jeelani G, Nozaki T
Abstract
Entamoeba histolytica is an enteric protozoan parasite that causes hemorrhagic dysentery and extraintestinal abscesses in millions of inhabitants of endemic areas. The genome of E. histolytica has already been sequenced and used to predict the metabolic potential of the organism. Since nearly 56% of the E. histolytica genes remain unannotated, correlative 'omics' analyses of genomics, transcriptomics, proteomics, and biochemical metabolic profiling are essential in uncovering new, or poorly understood metabolic pathways. Metabolomics aims at understanding biology by comprehensive metabolite profiling. In this review, we discuss recent metabolomics approaches to elucidate unidentified metabolic systems of this pathogen and also discuss future applications of metabolomics to understand the biology and pathogenesis of E. histolytica.
PMID: 24950028 [PubMed - as supplied by publisher]

Source: Current Opinion in Microbiology - June 17, 2014 Category: Microbiology Authors: Jeelani G, Nozaki T Tags: Curr Opin Microbiol Source Type: research