The anti ‐migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel

Conclusion and ImplicationsActivation of TRPA1 channels by isopetasin results in excitation of neuropeptide‐containing nociceptors, followed by marked heterologous neuronal desensitization. Such atten uation in pain and neurogenic inflammation may account for the anti‐migraine action of butterbur.

Source: British Journal of Pharmacology - July 20, 2017 Category: Drugs & Pharmacology Authors: Silvia Benemei, Francesco De Logu, Simone Li Puma, Ilaria Maddalena Marone, Elisabetta Coppi, Filippo Ugolini, Wolfgang Liedtke, Federica Pollastro, Giovanni Appendino, Pierangelo Geppetti, Serena Materazzi, Romina Nassini Tags: RESEARCH PAPER Source Type: research