The utility of empirically assigning ancestry groups in cross-population genetic studies of addiction.
CONCLUSIONS: We were able to create more genetically homogenous groups and reduce sample and marker loss through cross-ancestry meta-analysis, potentially increasing power to detect etiologically relevant variation. Our approach provides a framework for empirically assigning genetic ancestry groups which can be applied to other ethnically diverse genetic studies.
SCIENTIFIC SIGNIFICANCE: Given the important public health impact and demonstrable gains in statistical power from studying diverse populations, empirically sound practices for genetic studies are needed. (Am J Addict 2017;XX:1-8).
PMID: 28714599 [PubMed - as supplied by publisher]
Source: American Journal on Addictions - Category: Addiction Authors: Peterson RE, Edwards AC, Bacanu SA, Dick DM, Kendler KS, Webb BT Tags: Am J Addict Source Type: research
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