Colorectal Cancer Stem Cells Acquire Chemoresistance through the Upregulation of FBXW7 and the Consequent Degradation of c ‐Myc

In conclusion, our study revealed that a CSC‐specific FBXW7‐regulatory mechanism is strongly associated with resistance to chemotherapeutic agents. Inhibition of FBXW7‐upregulation in CSCs following chemotherapy may enhance the response to anticancer agents and represents an attractive strategy for the elimination of colorectal CSCs. This article is protected by copyright. All rights reserved.

LGR5(+) colorectal CSCs are proliferative and highly expressing c‐Myc with the absence of anticancer agents. During the cell cycle arrest caused by the anticancer agents, c‐Myc expression was substantially decreased in colorectal CSCs through FBXW7 upregulation. Inhibition of FBXW7‐upregulation in CSCs following chemotherapy may enhance the response to anticancer agents.

Source: Stem Cells - July 11, 2017 Category: Stem Cells Authors: Daisuke Izumi, Takatsugu Ishimoto, Keisuke Miyake, Tsugio Eto, Kota Arima, Yuki Kiyozumi, Tomoyuki Uchihara, Junji Kurashige, Masaaki Iwatsuki, Yoshifumi Baba, Yasuo Sakamoto, Yuji Miyamoto, Naoya Yoshida, Masayuki Watanabe, Ajay Goel, Patrick Tan, Hideo Tags: Cancer Stem Cells Source Type: research