Therapeutic concentrations of digitoxin inhibit endothelial focal adhesion kinase and angiogenesis induced by diverse growth factors

Conclusions and implicationsOur results show that therapeutic concentrations of digitoxin inhibit angiogenesis and FAK activation by diverse pro‐angiogenic stimuli. These novel findings suggest a potential repositioning of digitoxin as a broad‐spectrum antiangiogenic drug for diseases where pathological angiogenesis is involved.

Source: British Journal of Pharmacology - July 8, 2017 Category: Drugs & Pharmacology Authors: Annalisa Trenti, Elisabetta Zulato, Lorenza Pasqualini, Stefano Indraccolo, Chiara Bolego, Lucia Trevisi Tags: RESEARCH PAPER Source Type: research