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Artificial bile ducts grown in lab & transplanted into mice could help treat liver disease

(University of Cambridge) Cambridge scientists have developed a new method for growing and transplanting artificial bile ducts that could in future be used to help treat liver disease in children, reducing the need for liver transplantation.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Conclusions Older donor age and prolonged warm ischaemia time are independent predictors of HCV recurrence after LDLT, and early treatment with the direct-acting sofosbuvir is helpful in resolving the problem of post-LT HCV recurrence.
Source: Arab Journal of Gastroenterology - Category: Gastroenterology Source Type: research
Authors: Biswas S, Ghose S Abstract Several investigations have revealed that liver diseases exhibit gender biases, but identifying the root causes of such biases has been challenging. Evidence of gender differences in liver function is present from the early stage of embryonic development. The differences in access to care and treatment as well as diagnostic deliberation may affect gender-specific differences in liver disease progression. Apart from the pathogenesis, xenobiotic metabolism, immune responses, gene expressions, mitochondrial function, lipid composition, and enzyme activities also differ in this sexua...
Source: Frontiers in Bioscience - Scholar - Category: Biomedical Science Tags: Front Biosci (Schol Ed) Source Type: research
Source: Liver Transplantation - Category: Transplant Surgery Authors: Tags: Editorial Source Type: research
The sickest‐first principle in donor‐liver allocation can be implemented by allocating organs to patients with cirrhosis with the highest Model for End‐Stage Liver Disease (MELD) scores. For patients with other risk factors, standard exceptions (SEs) and nonstandard exceptions (NSEs) have been developed. We investigated whether this system of matched MELD scores achieves similar outcomes on the liver transplant waiting list for various diagnostic groups in Eurotransplant (ET) countries with MELD‐based individual allocation (Belgium, the Netherlands, and Germany). A retrospective analysis of the ET wait‐list outfl...
Source: Liver Transplantation - Category: Transplant Surgery Authors: Tags: Original Article Source Type: research
The evidence is insufficient for safe use of elderly donors in adult‐to‐adult living donor liver transplantation (LDLT). The aim of this study was to evaluate the outcomes of right lobe LDLT by donor age (≥55 versus 
Source: Liver Transplantation - Category: Transplant Surgery Authors: Tags: Original Article Source Type: research
AbstractBiliary atresia (BA) is a rare neonatal cholestatic disease which leads to progressive obliterative cholangiopathy, resulting in biliary obstruction and jaundice. The standard surgical treatment is hepatoportoenterostomy (Kasai operation). Although approximately 50% of the affected infants would require liver transplantation within the first 2  years of life, the other 50% of the patients can live for years with their native liver, despite the progression of cirrhosis and chronic liver disease. Many of these patients will be affected by long-term complications such as repeated cholangitis, portal hypertension,...
Source: Pediatric Surgery International - Category: Surgery Source Type: research
Conclusions: Implementation of the Share 35 allocation policy has a significant effect on outcomes by improving organ access and minimizing candidate waiting times. Recipients achieving a MELD of 40 or higher at our center post–Share 35 had an improved 1-year graft survival. However, nearly 40% remained hospitalized for more than 4 weeks posttransplant, and 20% were discharged to an acute care facility.
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science-Liver Source Type: research
Conclusions: The liver transplant waitlist size will remain static over the next decade due to patient dropout. Liver transplant candidates will be older, more likely to have nonalcoholic steatohepatitis and will wait for transplantation longer even when listed at a competitive MELD score. There will continue to be significant heterogeneity among transplant regions where some patients will be more likely to drop out of the waitlist than receive a transplant.
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science-Liver Source Type: research
This article originally appeared on Health.com
Source: TIME.com: Top Science and Health Stories - Category: Consumer Health News Authors: Tags: Uncategorized public health Source Type: news
We read with interest the study by Nadim et al[1] identifying inequality in organ allocation for patient awaiting liver transplant (LT) in the United States (U.S.). In depth, the Model for End-stage Liver Disease (MELD) score is artificially capped at 40 and thus actually disadvantages the sickest patients with end-stage liver diseases. In Nadim et al.[1] study, Figure 1 presents exponential increased the number of transplanted patients with MELD ≥ 40. As response to the increased demand of this population since year 2002, the “Share 35” that prioritized patients with MELD ≥ 35 within the donor’s Or...
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
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