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Artificial bile ducts grown in lab & transplanted into mice could help treat liver disease

(University of Cambridge) Cambridge scientists have developed a new method for growing and transplanting artificial bile ducts that could in future be used to help treat liver disease in children, reducing the need for liver transplantation.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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This article reviews the research progress for gut microbial a lterations and liver transplantation. Especially, this work also evaluates research on the management of gut microbial alteration and the prediction of possible injuries utilizing microbial alteration during liver transplantation. In addition, we propose possible directions for research on gut micro bial alteration during liver transplantation and offer a hypothesis on the utilization of microbial alteration in liver transplantation. The aim is not only to predict perioperative injuries but also to function as a method of treatment or even inhibit the rejection...
Source: Frontiers of Medicine - Category: General Medicine Source Type: research
Researchers at Yokohama City University and Cincinnati Children’s Center for Stem Cell and Organoid Medicine have developed a large-scale method to produce bioengineered liver tissue from human induced pluripotent stem cells (iPSCs). The technique could provide viable, consistently produced liver transplants, offering hope to patients with liver disease. One of the limitations faced by scientists trying to grow certain human cells in the lab for therapeutic purposes is the need to include animal cells in the same environment to help the human cells grow. Such animal cells produce substances that could cause negative...
Source: Medgadget - Category: Medical Devices Authors: Tags: Genetics Materials Surgery Source Type: blogs
Researchers can create functional organ tissue in small quantities, building few-millimeter-sized structures known as organoids. Yet because there is still no reliable approach to the creation of the capillary networks required to support thick tissue sections, this cannot yet scale up to the production of full-size replacement organs. That may not be a roadblock for organs such as the liver and kidney, which are responsible for what are essentially chemical manufacture and filtration tasks; in this case the large-scale structure of the organ isn't as important as the small-scale structure, and much of the organ might be t...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Conclusion, Diagnosing lung function abnormality preoperatively may help in optimizing lung functions of chronic liver disease patients in peri-operative period. Small sample size being limitation of our study may be a larger study would help in establishing significance of association and correlation which are not statistically significant in our study.Referrences:[1] Siemieniako A, Pogorzelska J, Łapiłski TW, Flisiak R. [Respiratory functional impairment in patients with liver cirrhosis]. Pol Merkur Lekarski. 2011 Nov;31(185):274-7.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Others Source Type: research
Summary BackgroundAntiviral therapy for hepatitis C has the potential to improve liver function in patients with decompensated cirrhosis. AimsTo examine the virological response and effect of viral clearance in patients with decompensated hepatitis C cirrhosis all with MELD scores ≥15 following sofosbuvir/daclatasvir ± ribavirin. MethodsWe prospectively collected data on patients who commenced sofosbuvir/daclatasvir for 24‐weeks under the Australian patient supply program (TOSCAR) and analysed outcomes including sustained viral response at 12 weeks (SVR12), death and transplant. Results108 patients (M/F, 79/29;...
Source: Alimentary Pharmacology and Therapeutics - Category: Drugs & Pharmacology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Model for end-stage liver disease (MELD) score is the most frequently used method to prioritise patients with end-stage livers disease for liver transplantation and it is calculated using serum levels of bilirubin and creatinine and the international normalized ratio (INR) [1]. Despite its strong predictive value, disease severity is underestimated in about 15-20% pf cirrhotic patients by the MELD score, resulting in an inaccurate prediction of survival [2]. Amongst others, conditions such as hyponatremia and hypoalbuminemia have been identified as additional risk factors for impaired waiting list survival.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
Authors: Lala SG, Britz R, Botha J, Loveland J Abstract Paediatric liver transplantation (PLT) is the only therapeutic option for many children with end-stage chronic liver disease or irreversible fulminant hepatic failure and is routinely considered as a therapy by paediatric gastroenterologists and surgeons working in developed countries. In South Africa (SA), a PLT programme is available at Red Cross War Memorial Children's Hospital in Cape Town since November 1991, and another has rapidly developed at the Wits Donald Gordon Medical Centre in Johannesburg over the past decade. However, for most children with pro...
Source: South African Medical Journal - Category: African Health Tags: S Afr Med J Source Type: research
This article reviews some of the most common vascular and non-vascular complications after paediatric liver transplantation, and the interventional radiology techniques used to diagnose and treat them. PMID: 29183451 [PubMed]
Source: South African Medical Journal - Category: African Health Tags: S Afr Med J Source Type: research
Authors: Horslen S Abstract Acute liver failure (ALF) was relatively easy to recognise in the days before liver transplantation became available as rescue therapy, because the diagnosis was based on end-stage disease manifestations such as profound coagulopathy, jaundice, encephalopathy and cerebral edema (in a patient with no history of chronic liver disease). These criteria no longer help us in an era when we struggle to define which patients are going to progress to this end-stage picture in the time necessary for evaluation and listing for life-saving transplantation. Ideally, identifying which patients wi...
Source: South African Medical Journal - Category: African Health Tags: S Afr Med J Source Type: research
Authors: Loveland J Abstract Paediatric hepatobiliary treatment, including hepatology, paediatric surgery and transplantation, is classified as quaternary and tertiary care and is difficult to access in South Africa. A dedicated part 2 of the SAMJ presents the South African experience together with articles by international experts in the field. PMID: 29183444 [PubMed]
Source: South African Medical Journal - Category: African Health Tags: S Afr Med J Source Type: research
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