Artificial bile ducts grown in lab & transplanted into mice could help treat liver disease

(University of Cambridge) Cambridge scientists have developed a new method for growing and transplanting artificial bile ducts that could in future be used to help treat liver disease in children, reducing the need for liver transplantation.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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AbstractBackgroundAcute kidney injury in the setting of alcoholic liver disease portends a poor prognosis without liver transplant.AimsUsing a tertiary care population, we aimed to evaluate the outcomes of renal replacement therapy in patients with alcoholic liver disease and acute kidney injury with  
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
I read with great interest the review article published recently by Mindikoglu et  al1 and would like to congratulate the authors on their eloquent update on hepatorenal syndrome (HRS). As pointed out distinctly, HRS continues to be a significant problem faced by clinicians who are actively involved in managing patients with advanced liver disease with ascites. HRS type 1 is a t ype of rapidly progressive acute kidney injury and is associated with a median survival of only approximately 4 weeks. It thus becomes extremely crucial to predict the subset of patients who are likely to be nonresponsive to vasoconstrictor th...
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
Authors: Yu YB, Song Y, Chen Y, Zhang F, Qi FZ Abstract Mesenchymal stem cells (MSCs) are considered to be an ideal source for the cell therapy of end‑stage liver diseases. Umbilical cord (UC)‑MSCs can be obtained via a non‑invasive procedure and can be easily cultured, making them potentially superior candidates for cell transplantation when compared with MSCs from other sources. In the present study, UC‑MSCs were induced to differentiate into hepatocytes and were compared with bone marrow (BM)‑MSCs for their hepatic differentiation potential. UC‑MSCs showed significantly higher proliferation than BM...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Publication date: Available online 20 June 2018 Source:Pharmacological Research Author(s): Alex Evangelista do Amaral, Michele Patrícia Rode, Julia Cisilotto, Telma Erotides da Silva, Josiane Fischer, Camila Matiollo, Elayne Cristina de Morais Rateke, Janaína Luz Narciso-Schiavon, Leonardo Lucca Schiavon, Tânia Beatriz Creczynski-Pasa MicroRNAs (miRNAs) have remarkable potential as diagnostic and prognostic markers because of their roles in disease pathogenesis. miRNAs can be released into the bloodstream, where they are sufficiently stable to be detected noninvasively. Here, we prospectively evaluated...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
ConclusionsHealthy donor FMT for SAH improves survival beyond what is offered by current therapies and can function as a cost-effective bridge to liver transplant (LT) or for improving transplant-free survival. Larger studies and randomized trials are unmet needs.
Source: Indian Journal of Gastroenterology - Category: Gastroenterology Source Type: research
The changing frequency in the listing of patients with end-stage HCV-induced liver disease for transplant, and the improvement of the typically impaired post-transplant survival seen in these patients, can be taken as early and strong indicators of direct acting antiviral (DAA) therapy ’s positive impact on HCV-associated disease burden. The study by Crespo et al. compared the composition of the liver transplant waiting list and the early post-transplant survival in the years before and after the availability of DAAs.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Editorial Desk Source Type: research
One of the major obstacles facing stem cell therapy is the limited number of functional stem cells available after transplantation due to the harsh microenvironment surrounding the damaged tissue. The aim of t...
Source: Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Research Source Type: research
CONCLUSION: Low testosterone levels are associated with sarcopenia in male cirrhotic patients. The potential therapeutic effect of testosterone to reverse sarcopenia in these patients warrants evaluation in future trials. PMID: 29893704 [PubMed - in process]
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
on JM Abstract All patients with elevated transaminases in France should be tested for HEV infection. HEV can cause severe hepatitis, in particular in patients with chronic liver disease, pregnant women and the elderly. Extra-hepatic manifestations including a number of neurologic syndromes, thrombopenia and renal injury have been described. HEV can cause chronic infection in immunosuppressed patients, in particular in organ-transplant recipients, patients with hematological malignancies and individuals with HIV. In patients with hematological malignancies, viral clearance can occur at the time of remission, with ...
Source: Presse Medicale - Category: General Medicine Authors: Tags: Presse Med Source Type: research
AbstractPurpose of ReviewPrimary sclerosing cholangitis (PSC) is a progressive cholestatic liver disease for which specific medical therapy is not available. The goals of treatment are primarily early detection and management of complications. In this review, we discuss novel therapies under evaluation and provide the foundation for surveillance strategies.Recent FindingsDrugs under investigation include norursodeoxycholic acid, nuclear receptor agonists, anti-fibrotics, antibiotics, and anti-inflammatory drugs. Endoscopic therapy is indicated for symptomatic dominant strictures and in the work-up of malignancies. Recently...
Source: Current Gastroenterology Reports - Category: Gastroenterology Source Type: research
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