Structural analysis of relevant drug targets for Alzheimer's disease

(Bentham Science Publishers) Alzheimer's Disease (AD) is classified as a neurodegenerative non-curable disease that affects millions worldwide. Current drugs have side effects that are significant. In AD, the beta-amyloid precursor protein that is critical for normal neuronal growth, survival and repair, is improperly cleaved by specific aspartic proteases, which create fragments that form plaques of amyloid beta. These fragments aggregate outside neurons and create plaques which lead to destruction of neural signaling.
Source: EurekAlert! - Biology - Category: Biology Source Type: news