Analysis of pathways activation landscape in oral squamous cell carcinoma and pre-neoplastic lesions

(InSilico Medicine, Inc.) Oral dysplastic lesions are considered precursors of OSCC. However only a subset of such lesions progress to invasive cancer. There is an urgent need for biomarkers, which might assign a risk for cancer development in patients with premalignant lesions. Scientists at the Johns Hopkins University alongside collaborators from Insilico Medicine, Inc, have applied iPANDA, a novel approach for analyzing high-throughput transcriptomic datasets, to identify the earliest signaling harbingers of malignant transition.
Source: EurekAlert! - Biology - Category: Biology Source Type: news