Differential sensitivity of CSF markers of p-tau and t-tau to in vivo tau deposition assessed with [18F]-AV-1451 in typical and atypical Alzheimers disease

Conclusion: Although both CSF-markers of p-tau and t-tau do not distinguish between AD types, global in vivo tau deposition and p-tau showed a selective association in typical but not atypical AD. Although preliminary, this result suggests that CSF tau marker in atypical AD do not reflect the extent of the pathological tau burden. We additionally identified a distinct spatial signature of each marker to in vivo regional tau burden in typical and atypical AD which may relate to the generally different distribution of tau deposits in different disease entities. We conclude that in vivo tau imaging can differentiate typical from atypical AD and allow better insights into the neurodegenerative spread of the disease, compared to CSF markers of tau. Research Support: NA.

Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Bischof, G., Johannis, W., Faber, J., Neumaier, B., Onur, O., Kukolja, J., Drzezga, A., Van Eimeren, T. Tags: Novel Clinical Applications in Tauopathy and Epilepsy Source Type: research