Feasibility of Absolute Quantitation of Myocardial 99mTc-DPD Uptake in Patients with Suspected Transthyretin Cardiac Amyloidosis

Conclusion: Absolute SPECT quantitation of cardiac 99mTc-DPD uptake is feasible using Q.Metrix. Initial findings suggest significantly lower cardiac concentration and significantly lower cardiac %ID in PS 1, but no significant differences in %ID between PS 2 and 3. Further assessment in larger patient cohorts is needed to determine the value of SPECT quantitation over visual assessment and planar quantitation in ATTR and its role in diagnosis and potentially follow up/treatment response assessment. Research Support: GE Healthcare

Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Ben-Haim, S., Smekhov, M., Goshen, E., O'Mahoney, E., Arad, M., Elliott, P., Medini, I., Bar-Shalev, A., Bomanji, J., Menezes, L. Tags: The ' New Cardiomyopathies: Sarcoid, Amyloid, and Chemotherapy Source Type: research