Successful Liver Transplantation for Transient Abnormal Myelopoiesis-Associated Liver Failure.

We report an infant with DS and TAM who developed end-stage liver failure. Liver dysfunction progressed even after blast cells disappeared from the circulation. He underwent a living-donor liver transplantation at 56 days of life without surgical complications. The explanted liver showed atrophy and severe fibrosis without leukemic cell infiltration. The posttransplant course was favorable with no hematological abnormality. He is doing well 8 months after transplantation. To the best of our knowledge, this report is the first showing that liver transplantation might be a treatment option for TAM-related liver failure.
PMID: 28558383 [PubMed - as supplied by publisher]

Source: Neonatology - May 31, 2017 Category: Perinatology & Neonatology Authors: Yasuoka K, Inoue H, Tanaka K, Fujiyoshi J, Matsushita Y, Ochiai M, Koga Y, Matsuura T, Taguchi T, Ohga S Tags: Neonatology Source Type: research