Autologous hematopoietic stem cell transplantation for MS: Safer than previously thought

Multiple sclerosis (MS) is likely initiated by an autoimmune response that targets the CNS. A common conceptualization of the early stages of MS is that immunocompetent cells of the adaptive immune system, recognizing hitherto unknown autoantigens, invade the CNS. These invasions happen in discrete attacks in focal areas of the CNS, giving rise to the well-known features of blood–brain barrier breakdown and lesion formation visible on MRI. This immune process is critically dependent on immunologic memory, and with time a pool of autoreactive lymphocytes is maintained. What if these immunologic memories could be erased?
Source: Neurology - Category: Neurology Authors: Tags: Clinical trials Systematic review/meta analysis, Multiple sclerosis EDITORIALS Source Type: research