Syndecan ‐1 Limits the Progression of Liver Injury and Promotes Liver Repair in Acetaminophen‐Induced Liver Injury

Conclusion: These results demonstrate that 2‐O‐sulfated domains in syndecan‐1 HS halt disease progression and promote liver repair by enhancing hepatocyte survival in APAP‐induced liver injury. We propose that syndecan‐1 is a critical endogenous factor that controls the balance between pro‐survival signaling and apoptosis in hepatocytes in APAP liver disease. This article is protected by copyright. All rights reserved.
Source: Hepatology - Category: Internal Medicine Authors: Tags: Liver Injury and Regeneration Source Type: research