Association Between Inflammatory Skin Disease and Cardiovascular and Cerebrovascular Co-Morbidities in US Adults: Analysis of Nationwide Inpatient Sample Data

The objective of this study was to determine whether these inflammatory skin diseases are associated with increased cardiovascular/cerebrovascular risk and/or disease.MethodsWe analyzed data from the 2002 –2012 National Inpatient Sample, including a representative 20% sample of all US hospitalizations (n = 72,108,077 adults).ResultsIn multivariate logistic regression models with propensity score matching, patients hospitalized with versus without a diagnosis the inflammatory skin diseases examined had higher odds of obesity (odds ratio [95% confidence interval] for pemphigus: 1.16 [1.05 –1.29]; BP 1.14 [1.06–1.23]; AD-E: 1.82 [1.79–1.86]; psoriasis: 2.36 [2.32–2.41]; hidradenitis: 2.79 [2.59–3.01]). Inflammatory skin disease was also associated with significantly higher odds of different cardiovascular risk factors, including hypertension (pemphigus: 1.39 [1.31–1.48]; B P 1.96 [1.88–2.05]; AD-E: 1.19 [1.17–1.21]; psoriasis: 1.61 [1.59–1.64]), and diabetes mellitus with complications (pemphigus: 1.34 [1.18–1.52]; BP: 2.06 [1.90–2.24]; AD-E: 1.13 [1.10–1.17]; psoriasis: 1.39 [1.35–1.44]), as well as vascular, cardiovascular, and cerebrovascular disease, including peripheral vascular disease (pemphigus: 1.14 [1.00–1.30]; BP: 1.83 [1.69–1.98]; AD-E: 1.18 [1.14–1.22]; psoriasis: 1.32 [1.28–1.35]), peripheral and visceral atherosclerosis (BP: 1.67 [1.53–1.81];...
Source: American Journal of Clinical Dermatology - Category: Dermatology Source Type: research

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