News American Association for Cancer Research Annual Meeting 2017

Results from an open-label, phase 2, basket trial assessing the clinical activity of neratinib in 141 patients with either HER2-mutant or HER3-mutant tumours were presented by David Hyman (Memorial Sloan Kettering Cancer Center, New York, NY, USA). Patients with HER2-mutant lung cancer (n=26), breast cancer (n=25), bladder or urinary tract cancer (n=16), colorectal cancer (n=12), biliary tract cancer (n=9), endometrial cancer (n=7), cervical cancer (n=5), gastro-oesophageal cancer (n=5), and ovarian cancer (n=4), as well as patients with solid tumours not otherwise specified (n=32; of which 15 were HER2-mutant-postive and 17 were HER3-mutant-postive), were enrolled in this study.
Source: The Lancet Oncology - Category: Cancer & Oncology Authors: Tags: News Source Type: research

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In conclusion, this study elucidated that combination of cisplatin and XAV-939 exerted cytotoxic and genotoxic effect to abrogate CSC mediated chemoresistance in HNSCC in synergistic manner.
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - Category: Genetics & Stem Cells Source Type: research
Publication date: Available online 17 August 2019Source: Revista Clínica Española (English Edition)Author(s): J. Masip, J.R. Germà LluchAbstractRecent epidemiological studies have shown that alcohol consumption can increase the risk of arterial hypertension, atrial fibrillation and gastrointestinal and breast cancer. Various sectors are therefore promoting abstinence from alcohol. However, light alcohol consumption has once again been shown to reduce the risk of myocardial infarction and diabetes but with an unclear effect on cerebrovascular disease. The decision to consume alcohol should therefore be ...
Source: Revista Clinica Espanola - Category: Internal Medicine Source Type: research
Publication date: Available online 17 August 2019Source: Surgery (Oxford)Author(s): Tim LaneAbstractUpper tract transitional cell carcinoma is a lethal disease with half the patients dead within 5 years of diagnosis. Unlike urothelial tumours arising in the bladder, the disease is more likely to be invasive at the time of diagnosis and in part reflects the poorer prognosis. It is a biologically aggressive disease with a high chance of recurrence even after local control. Diagnosis is made by a combination of upper tract imaging, urine cytology and ureteroscopic biopsy. Organ-confined disease is amenable to radical surgery,...
Source: Surgery (Oxford) - Category: Surgery Source Type: research
This article aims to summarize the current knowledge of prostate cancer and treatment options available.
Source: Surgery (Oxford) - Category: Surgery Source Type: research
Publication date: Available online 17 August 2019Source: Surgery (Oxford)Author(s): Jameel Mushtaq, Ramesh Thurairaja, Rajesh NairAbstractUrothelial carcinoma of the bladder is the most common malignancy affecting the urinary tract. This review examines the current standards in the diagnosis and management of this disease. Cystoscopy and urine cytology remain important tools in the diagnosis and follow-up of bladder cancer. Alternatives include photodynamic diagnosis, narrow band imaging and professional image enhancement which may improve detection of tumours. En-bloc resection using either laser or electrocautery shows p...
Source: Surgery (Oxford) - Category: Surgery Source Type: research
ConclusionsWe present the rare case of a patient with surgically resected locally advanced rectal cancer who demonstrated an impressive pCR with preoperative chemotherapy, which included FOLFOX plus bevacizumab.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
CONCLUSIONWe present a case of SCC in the anal canal with liver metastasis presenting as a hepatic pseudocyst.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
ConclusionIn this study, we found that over-expression of TINCR may influence the tumor size and contribute to the poor prognosis of cancer.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
ConclusionCC shows an indolent clinical behavior, with a low recurrence rate after radical surgery. The diagnosis of this rare tumor is typically made after surgery. An aggressive approach is required with curative intents.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: Available online 17 August 2019Source: Pathology - Research and PracticeAuthor(s): X.X. Yang, P. WangAbstractMicroRNA (miRNA) plays a significant role in suppressing the occurrence and development of tumor by inhibiting the translation of target proteins. Although previous researches have verified many miRNAs’ functions in bladder cancer (BC), the function of miR-188-5p and miR-141-3p in BC still remains unknown. Our experiment manifested that miR-188-5p and miR-141-3p were highly expressed in BC tissues and cells, which indicated a poor prognosis. In vitro functional assays suggested that down-regu...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
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