SFPQ/PSF-TFE3 Renal Cell Carcinoma (RCC): A Clinicopathologic Study Emphasizing Extended Morphology and Reviewing the Differences between SFPQ-TFE3 RCC and the Corresponding Mesenchymal Neoplasm despite an Identical Gene Fusion

Xp11 translocation renal cell carcinoma (RCC) with SFPQ/PSF-TFE3 gene fusion is a rare epithelial tumor. Of note, the appearance of the gene fusion does not necessarily mean that it is renal cell carcinoma. The corresponding mesenchymal neoplasms, including Xp11 neoplasm with melanocytic differentiation, TFE3 rearrangement-associated perivascular epithelioid cell tumor (PEComa) and melanotic Xp11 translocation renal cancer, can also harbor the identical gene fusion. However, the differences between Xp11 translocation RCC and the corresponding mesenchymal neoplasm have only recently been described.
Source: Human Pathology - Category: Pathology Authors: Source Type: research