Effect of polymorphisms on TGFB1 on allergic asthma and helminth infection in an African admixed population.

CONCLUSION: Individuals with TGF-β1 polymorphisms have an increased susceptibility to helminth infections and a lower risk of developing allergy. These studies suggest that immune modulation of allergic disease results not only from environmental factors but also from genetic susceptibility and IL-10 production.
PMID: 28284979 [PubMed - as supplied by publisher]

Source: Annals of Allergy, Asthma and Immunology - March 7, 2017 Category: Allergy & Immunology Authors: Costa RD, Figueiredo CA, Barreto ML, Alcantara-Neves NM, Rodrigues LC, Cruz AA, Vergara C, Rafaels N, Foster C, Potee J, Campbell M, Mathias RA, Barnes KC Tags: Ann Allergy Asthma Immunol Source Type: research