Molecular characterization and in-silico analysis of the tissue inhibitor of metalloproteinases-3 (TIMP-3) gene of canine mammary tumor.

CONCLUSIONS: The three dimensional structure of TIMP-3 was generated and its interactions with MMP-2 and MMP-9, demonstrates the role of key binding residues. Until now, no structural details were available for canine TIMP-3 proteins, hence this study will broaden the horizon towards understanding the structural and functional aspects of this proteins in canine.
PMID: 28215146 [PubMed - as supplied by publisher]

Source: Combinatorial Chemistry and High Throughput Screening - February 16, 2017 Category: Chemistry Authors: Yadav PK, Yadav BS, Panigrahi PN, Tripathi V, Chaturvedi N, Kataria M Tags: Comb Chem High Throughput Screen Source Type: research