Phosphate overload directly induces systemic inflammation and malnutrition as well as vascular calcification in uremia.

Phosphate overload directly induces systemic inflammation and malnutrition as well as vascular calcification in uremia. Am J Physiol Renal Physiol. 2014 May 7; Authors: Yamada S, Tokumoto M, Tatsumoto N, Taniguchi M, Noguchi H, Nakano T, Masutani K, Ooboshi H, Tsuruya K, Kitazono T Abstract Hyperphosphatemia contributes to increased cardiovascular mortality through vascular calcification (VC) in patients with chronic kidney disease (CKD). Malnutrition and inflammation are also closely linked to increased risk of cardiovascular death in CKD. However, the effects of Pi overload on inflammation and malnutrition remain to be elucidated. The aim of the present study was to investigate the effects of dietary phosphate loading on the interaction among inflammation, malnutrition and VC in CKD. We used control rats fed normal diets and adenine-induced CKD rats fed diets with different phosphate concentrations ranging from 0.3% to 1.2% for 8 weeks. CKD rats showed dietary phosphate concentration-dependent increases in serum and tissue levels of tumor necrosis factor-α, and urinary and tissue levels of oxidative stress markers, and developed malnutrition (decrease in body weight, serum albumin and urinary creatinine excretion), VC and premature death without affecting kidney function. Treatment with 6% lanthanum carbonate blunted almost all changes induced by phosphate overload. Regression analysis showed that serum phosphate levels closely co...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research