International Society for Heart & Lung Transplantation/HeartWare Award for Translational Research in Mechanical Circulatory Support

International Society for Heart &Lung Transplantation/HeartWare Award for Translational Research in Mechanical Circulatory Support The ISHLT/HeartWare Award for Translational Research in MCS is a one-year award in the amount of $65,000. The APPLICATION DEADLINE is JUNE 2, 2014. AWARD DECISION AND NOTIFICATION: JULY 15, 2014. If you have any questions about the application process, please contact Phyllis Glenn at 972-490-9495 or phyllis.glenn@ishlt.org. PURPOSE: The purpose of the Award is to support research utilizing MCS that would result in an increased understanding of the biologic effects, use as sole or combined therapy, insights into patient/MCS management, innovative use/application or improved outcomes for the treatment of heart failure. The Award is aimed to support rising stars in the field of mechanical circulatory support at a critical time in their career. The Award recipient will have already established a track record in the field of mechanical circulatory support and will aim to further develop their career in this area. The intent is that the Award will be for a junior faculty position dedicated to a career in the use of MCS as a treatment option for heart failure. It is anticipated that the individual will be clinician or clinician scientist at an active VAD/transplant program with a faculty appointment in either cardiology or cardiac surgery. ELIGIBILITY REQUIREMENTS: The applicant must have Board certification or be Board eligible (with...
Source: ScanGrants feed - Category: Research Authors: Source Type: funding

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Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Sarcoidosis is an increasingly prevalent systemic disease resulting in granulomatous inflammation.1,2 Cardiac sarcoidosis (CS) can manifest as systolic heart failure (HF) resulting in increased morbidity and mortality. CS that progresses to end-stage HF may benefit from left ventricular assist device (LVAD) therapy to improve outcomes.3 The treatment of myocardial inflammation, as determined by 18-fludeoxyglucose positron emission tomography (FDG-PET), with immunosuppressive agents is central to prevent adverse cardiovascular events such as ventricular arrhythmias and even death.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: CASE ANECDOTE, COMMENTS AND OPINIONS Source Type: research
Hepatic cirrhosis is a potential severe complication of chronic heart failure and has major implications on treatment options. In general, patients with cirrhosis are considered ineligible for isolated cardiac transplantation. Therefore, proper diagnosis of cirrhosis is paramount. The aim of this retrospective study is to explore the diagnostic value of abdominal ultrasound, hepatosplenic scan and abdominal computed tomography scan (CT scan) for liver disease secondary to advanced heart failure.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (564) Source Type: research
In this study, we investigated the link between AF and senescence markers through the assessment of protein expression in the tissue lysates of human appendages from patients in AF, including paroxysmal (PAF) or permanent AF (PmAF), and in sinus rhythm (SR). The major findings of the study indicated that the progression of AF is strongly related to the human atrial senescence burden as determined by p53 and p16 expression. The stepwise increase of senescence (p53, p16), prothrombotic (TF), and proremodeling (MMP-9) markers observed in the right atrial appendages of patients in SR, PAF, and PmAF points toward multiple inter...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In this study, researchers studied 438,952 participants in the UK Biobank, who had a total of 24,980 major coronary events - defined as the first occurrence of non-fatal heart attack, ischaemic stroke, or death due to coronary heart disease. They used an approach called Mendelian randomisation, which uses naturally occurring genetic differences to randomly divide the participants into groups, mimicking the effects of running a clinical trial. People with genes associated with lower blood pressure, lower LDL cholesterol, and a combination of both were put into different groups, and compared against those without thes...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
We examined human lung tissue from COPD patients and normal control subjects, and found a substantial increase in p16-expressing alveolar cells in COPD patients. Using a transgenic mouse deficient for p16, we demonstrated that lungs of mice lacking p16 were structurally and functionally resistant to CS-induced emphysema due to activation of IGF1/Akt regenerative and protective signaling. Fat Tissue Surrounds Skeletal Muscle to Accelerate Atrophy in Aging and Obesity https://www.fightaging.org/archives/2019/09/fat-tissue-surrounds-skeletal-muscle-to-accelerate-atrophy-in-aging-and-obesity/ Researchers her...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Giuseppe Ristagno1*, Francesca Fumagalli1, Barbara Bottazzi2, Alberto Mantovani2,3,4, Davide Olivari1, Deborah Novelli1 and Roberto Latini1 1Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research IRCCS, Milan, Italy 2Humanitas Clinical and Research Center-IRCCS, Milan, Italy 3Humanitas University, Milan, Italy 4The William Harvey Research Institute, Queen Mary University of London, London, United Kingdom The long pentraxin PTX3 is a member of the pentraxin family produced locally by stromal and myeloid cells in response to proinflammatory signals and microbial moieties. The p...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In this study they also showed PTX3 localized in NETs formed after neutrophil activation (5). Proteomics analysis revealed that PTX3 forms complexes with two anti-microbial proteins [azurocidin (AZU1) and myeloperoxidase (MPO)] associated to NETs (30). More recently, PTX3 localization in NETs has been confirmed, and the colocalization with AZU1 and MPO has been defined more accurately (31). Further investigation will be needed to understand the involvement of PTX3 interaction with AZU1 and MPO in their antibacterial role during NET formation. Regulation of Complement Activation PTX3 interaction with microorganisms is not...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This study defines a new clinically relevant concept of T-cell senescence-mediated inflammatory responses in the pathophysiology of abnormal glucose homeostasis. We also found that T-cell senescence is associated with systemic inflammation and alters hepatic glucose homeostasis. The rational modulation of T-cell senescence would be a promising avenue for the treatment or prevention of diabetes. Intron Retention via Alternative Splicing as a Signature of Aging https://www.fightaging.org/archives/2019/03/intron-retention-via-alternative-splicing-as-a-signature-of-aging/ In recent years researchers have inv...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Right ventricular failure (RVF) after LVAD implantation remains difficult to predict pre-operatively. As right heart failure is associated with muscle wasting, we hypothesized pectoralis muscle tissue attenuation quantified on pre-operative CT scans would enhance the prediction of RVF after LVAD implantation.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 24 Source Type: research
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