pH Alkalinization by Chloroquine Suppresses Pathogenic Burkholderia Type 6 Secretion System 1 and Multinucleated Giant Cells [Cellular Microbiology: Pathogen-Host Cell Molecular Interactions]

This study highlights the multiple mechanisms by which CLQ inhibits growth and virulence and suggests that CLQ be further tested and considered, in conjunction with antibiotic use, for the treatment of diseases caused by Burkholderia.

Source: Infection and Immunity - December 28, 2016 Category: Infectious Diseases Authors: Chua, J., Senft, J. L., Lockett, S. J., Brett, P. J., Burtnick, M. N., DeShazer, D., Friedlander, A. M. Tags: Cellular Microbiology: Pathogen-Host Cell Molecular Interactions Source Type: research