Microbiota dysbiosis: a new piece in the understanding of carcinogenesis puzzle.

Microbiota dysbiosis: a new piece in the understanding of carcinogenesis puzzle. J Med Microbiol. 2016 Oct 21;: Authors: García-Castillo V, Sanhueza E, McNerney E, Onate SA, García A Abstract Cancer is defined as an uncontrolled proliferation of malignant cells in a host and it is one of the main causes of death worldwide. Genetic and environmental factors play an important role in its development and the involvement of microbial communities has also recently been recognized. The close relationship that characterizes the colonization of human commensal communities involves health risks particularly when the homeostasis is disturbed. It has been hypothesized that this process may lead to cancer by modulating the inflammatory response of the host, by the production of carcinogenic metabolic products or by the production of toxins which disrupt the cell cycle. The metabolic effects of the intestinal microbiota have been studied in greater detail on the gastrointestinal tract, and it has been recognized that microbial communities of other body surfaces can affect either locally or at distance. In vitro and in vivo studies have allowed to characterize the microbiota and to establish a cause-effect relationship with some types of cancer. Nevertheless, despite the results, representative studies are necessary to validate the findings and definitively establish the role of microbiota on cancer development in order to open the possibility t...
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research