Dementia ‐related adverse events in PARADIGM‐HF and other trials in heart failure with reduced ejection fraction

ConclusionWe found no evidence that sacubitril/valsartan, compared with enalapril, increased dementia‐related AEs, although longer follow‐up may be necessary to detect such a signal and more sensitive tools are needed to detect lesser degrees of cognitive impairment. Further studies to address this question are warranted.

Source: European Journal of Heart Failure - October 31, 2016 Category: Cardiology Authors: Jane A. Cannon, Li Shen, Pardeep S. Jhund, S øren L. Kristensen, Lars Køber, Fabian Chen, Jianjian Gong, Martin P. Lefkowitz, Jean L. Rouleau, Victor C. Shi, Karl Swedberg, Michael R. Zile, Scott D. Solomon, Milton Packer, John J.V. McMurray, Tags: Original Article Source Type: research