Online calculator that tries to predict IVF success released

Conclusion This study aimed to develop a model that could predict the chances of a live birth over multiple cycles of in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI). The model used a large quantity of data taken from reliable UK medical records belonging to couples who had previously undergone IVF or ICSI. The model also benefits from being able to account for a large number of personal and treatment characteristics. The researchers developed two models for couples in both the pre-treatment and post-treatment phase of treatment cycles. They hope this online tool will serve as an aid for couples to shape expectations about what their overall chances are of having a baby after IVF or ICSI treatment, as well as allowing couples to make more informed decisions about their treatment. Although this is potentially very useful for both doctors and patients, it's important to bear in mind that every couple will have a different experience – models, no matter how sophisticated, are not necessarily able to reflect what happens in reality. And this tool includes very broad questions – for example, it asks if you have male factor infertility or tube problems. As such, it's not possible to add in your own specific data on factors like which fertility problem you or your partner may suffer from. If you're considering having fertility treatment, you can increase your chances of conception – whether you're woman or man – by quitting smokin...
Source: NHS News Feed - Category: Consumer Health News Tags: Pregnancy/child Source Type: news

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CONCLUSIONS These results revealed Stat3 is a new target of miR-125b-5p and revealed the mechanism of miR-125b-5p suppressing HypoT development. These findings provide a new target for HypoT therapy. PMID: 30027933 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
This study describes the first use of PGD for GJB2 associated non-syndromic deafness in Iran. GJB2 donor splicing site IVS1+1G>A mutation analysis was performed using Sanger sequencing for a total of 71 Iranian families with at least 1 deaf child diagnosed with non-syndromic deafness. In Vitro Fertilization (IVF) was performed, followed by PGD for a cousin couple with a 50% chance of having an affected child. Bi-allelic pathogenic mutations were found in a total of 12 families (~17 %); of which a couple was a PGD volunteer. The deaf woman in this family was homozygous and her husband was a carrier of the IVS1+1G>A ge...
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research
Yoon Mee Yang, Masato Fukui, Zhijun Wang, Fiona Miao, Margo J. Karriker, Ekihiro Seki
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Abstract The discovery of "oestrus-producing" hormones was a major research breakthrough in biochemistry and pharmacology during the early part of the 20th century. The elucidation of the molecular weight and chemical structure of major oxidative metabolites of dehydroepiandrosterone (DHEA) led to the award of the Nobel Prize in 1939 to Adolf Frederick Johann Butenandt and Leopold Ruzicka. Considered a bulk androgen in the circulation, DHEA and its sulfated metabolite DHEA-S can be taken up by most tissues where the sterols are metabolized to active androgenic and estrogenic compounds needed for growth a...
Source: Vitamins and Hormones - Category: Endocrinology Authors: Tags: Vitam Horm Source Type: research
Eat more fruits and vegetables, don ’ t put plastic containers in the microwave or dishwasher and check recycling codes to reduce exposure to chemicals.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Food Hazardous and Toxic Substances Hormones Pregnancy and Childbirth Containers and Packaging Endocrine Gland Bisphenol A (BPA) Children and Childhood Regulation and Deregulation of Industry Food Additives American Academy of Pediatri Source Type: news
Maternal&Child Nutrition, EarlyView.
Source: Maternal and Child Nutrition - Category: Nutrition Authors: Source Type: research
Cameron M. Wright, Richard Norman, Richard Varhol, Jacqueline Davis, Elizabeth Wilson-Taylor, Justin Dorigo, Suzanne Robinson
Source: Australian Journal of Primary Health - Category: Primary Care Authors: Source Type: research
AbstractPurpose of reviewThis manuscript addresses the risks for venous thromboembolism (VTE) during pregnancy and the associated challenges of both diagnosis and treatment.Recent findingsThe obstacles to diagnosis given lack of specificity of typical biomarkers to predict VTE in pregnancy, as well as the unique fetal and bleeding risks introduced by managing massive pulmonary embolism (PE) with thrombolytics or thrombectomy are highlighted.SummaryVTE during pregnancy and the postpartum window occurs at a 6 –10-fold higher rate compared with age-matched peers and is a major cause of morbidity and mortality. Hypercoag...
Source: Current Treatment Options in Cardiovascular Medicine - Category: Cardiology Source Type: research
AbstractHome visitation research remains on the forefront as policy makers look to evidence for programs they believe are worthy of investment, particularly in terms of child abuse prevention. A randomized controlled trial (N = 245) of the Healthy Families Arizona home visitation program was conducted. Outcomes were assessed across several key domains related to child abuse and neglect: safety and resources, parenting attitudes and behaviors, health and maternal outcomes, and mental health and coping. Findings revea led significant differences between the groups at both 6-month and 1-year follow-up assessment...
Source: Prevention Science - Category: Psychiatry & Psychology Source Type: research
AbstractMonitoring of changes in acute phase proteins following the treatment of endometritis can help us to improve treatment protocols. In total, 81 dairy cows affected by clinical endometritis were selected in 30  days in milk (DIM) and treated with hyperimmune serum. Cervical mucus cytology was used to determine the neutrophil percentage. Levels of amyloid A (SAA) and haptoglobin (Hp) in blood serum were measured just before and 2 weeks after the treatment. The cows were timed-inseminated with Heat Synch following the treatment, and pregnancy was diagnosed 35 ± 3 days after AI. Varia...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research
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