Scientists discover a link between DNA marks and chronic widespread muscle pain

Scientists at King’s College London, who we've funded, have found a link between changes in marks on the outside of DNA (epigenetics) and chronic widespread muscle pain, one of the main symptoms offibromyalgia. Fibromyalgia is a common long-term chronic condition that causes fatigue and widespread pain in muscles and bones.Despite its prevalence, the causes of fibromyalgia are poorly understood and there are limited treatments available. There are no diagnostic tests and it can't be detected using conventional tests such as scans or x-rays.The study published today (10 November) will help scientists towards the development of a blood test to diagnose fibromyalgia, which affects as many as one in every 25 people.Understanding genetic factorsDr Frances Williams, a lead researcher of this study said: "Fibromyalgia is influenced by genetic factors but there are many complicated steps between gene and disease. Identifying measurable epigenetic links is a major step forward."In addition, the results will inform future research in fibromyalgia as well as other chronic pain syndromes, such as irritable bowel syndrome."Stephen Simpson, our director of research and programmes, commented on the research:“There are millions of people in the UK who are living with the pain of fibromyalgia. This really exciting research is an important step forward in our understanding of how epigenetic differences between individuals can influence our likelihood of developing fibromyalgia and ...
Source: Arthritis Research UK - Category: Rheumatology Source Type: news