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Genetic features of myelodysplastic syndrome and aplastic anemia in pediatric and young adult patients.

This study shows that while any single specific bone marrow failure/myelodysplastic syndrome genetic disorder is rare, screening for these disorders in aggregate identifies a significant subset of patients with inherited bone marrow failure/myelodysplastic syndrome. PMID: 27418648 [PubMed - in process]
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research

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STOMACH cancer symptoms include a poor appetite, weight loss, and nausea. Treatment can include operations as well as changes to what you eat. Adapting your diet to include more of these foods could help to treat the condition.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
This report warns that reluctance to talk honestly about death is preventing people with cancer from dying'well'. It calls for Governments across the UK to honour their commitments to ensuring Advance Care Planning is used as an important part of a person-centred health service, so that people approaching the end of their lives receive the best care possible and their wishes for death and dying are fulfilled
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
AN artificial intelligence revolution to prevent 22,000 cancer deaths by 2033 was being unveiled today. Theresa May is challenging the NHS to transform healthcare.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
The prognostic value of high sensitivity C-reactive protein in a multi-ethnic population after>10 years of follow-up: The Multi-Ethnic Study of Atherosclerosis (MESA). Int J Cardiol. 2018 Aug 01;264:158-164 Authors: Cainzos-Achirica M, Miedema MD, McEvoy JW, Cushman M, Dardari Z, Greenland P, Nasir K, Budoff MJ, Al-Mallah MH, Yeboah J, Blumenthal RS, Comin-Colet J, Blaha MJ Abstract BACKGROUND: The prognostic value of hsCRP in contemporary multi-ethnic populations is unclear, particularly in statin users. The aim of this study was to characterize the prognostic utility of hsCRP for atheroscleroti...
Source: Atherosclerosis - Category: Cardiology Authors: Tags: Int J Cardiol Source Type: research
Abstract The molecular pathogenesis and classification of colorectal carcinoma are based on the traditional adenomaecarcinoma sequence, serrated polyp pathway, and microsatellite instability (MSI). The genetic basis for hereditary nonpolyposis colorectal cancer is the detection of mutations in the MLH1, MSH2, MSH6, PMS2, and EPCAM genes. Genetic testing for Lynch syndrome includes MSI testing, methylator phenotype testing, BRAF mutation testing, and molecular testing for germline mutations in MMR genes. Molecular makers with predictive and prognostic implications include quantitative multigene reverse transcriptas...
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Tags: Clin Lab Med Source Type: research
Abstract MicroRNAs (miRNAs) are poised to provide diagnostic, prognostic, and therapeutic targets for several diseases including malignancies for precision medicine applications. The miRNAs have immense potential in the clinical arena because they can be detected in the blood, serum, tissues (fresh and formalin-fixed paraffin-embedded), and fine-needle aspirate specimens. The most attractive feature of miRNA-based therapy is that a single miRNA could be useful for targeting multiple genes that are deregulated in cancers, which can be further investigated through systems biology and network analysis that may provid...
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Tags: Clin Lab Med Source Type: research
Authors: Stahlschmidt A, Novelo B, Alexi Freitas L, Cavalcante Passos S, Dussián-Sarria JA, Félix EA, Wajnberg Gamermann P, Caumo W, Cadore Stefani LP Abstract INTRODUCTION: Morbidity and mortality associated with urgent or emergency surgeries are high compared to elective procedures. Perioperative risk scores identify the non-elective character as an independent factor of complications and death. The present study aims to characterize the population undergoing non-elective surgeries at the Hospital de Clínicas de Porto Alegre and identify the clinical and surgical factors associated with death...
Source: Revista Brasileira de Anestesiologia - Category: Anesthesiology Tags: Rev Bras Anestesiol Source Type: research
CONCLUSIONS: Ring-shaped thread counter traction makes the most difficult duodenal ESD safer and easier without complications. PMID: 29764299 [PubMed - as supplied by publisher]
Source: Minimally Invasive Therapy and Allied Technologies - Category: Surgery Tags: Minim Invasive Ther Allied Technol Source Type: research
Novel concepts employing autologous, ex  vivo expanded natural regulatory T cells (nTreg) for adoptive transfer has potential to prevent organ rejection after kidney transplantation. However, the impact of dialysis and maintenance immunosuppression on the nTreg phenotype and peripheral survival is not well understood, but essential when assessing patient eligibility. The current study investigates regulatory T-cells in dialysis and kidney transplanted patients and the feasibility of generating a clinically useful nTreg product from these patients.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Clinical Investigation Source Type: research
In conclusion, our data show that clonal hematopoiesis emerges in the majority of patients with AA, including children and young adults, can be detected early in disease, and has a mutational spectrum largely distinct from MDS. Our results highlight that in the absence of morphologic features of myelodysplasia, the presence of clonal hematopoiesis with somatic mutations cannot be used to distinguish MDS from AA. Future longitudinal studies of clonal hematopoiesis in AA will help to explain differences in patients’ disease course, and will enable personalized treatment approaches in AA.Citation Format: Daria V. Babush...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Molecular and Cellular Biology Source Type: research
More News: Anemia | Aplastic Anemia | Cancer | Cancer & Oncology | Cancer in Adolescents | Cancer in Young Adults | Children | Genetics | Myelodysplastic Syndrome | Pediatrics | Study | Transplants