Genetic features of myelodysplastic syndrome and aplastic anemia in pediatric and young adult patients.

This study shows that while any single specific bone marrow failure/myelodysplastic syndrome genetic disorder is rare, screening for these disorders in aggregate identifies a significant subset of patients with inherited bone marrow failure/myelodysplastic syndrome. PMID: 27418648 [PubMed - in process]
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research

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Publication date: Available online 18 October 2018Source: Journal of Molecular LiquidsAuthor(s): H. Abramczyk, A. Imiela, A. ƚliwiƄskaAbstractLipids play an important role in many cellular processes. Raman-driven microscopy is one of the most powerful technique for analyzing the properties of lipids in cellular compartments offering lipid compositional mapping and more precise, faster, simpler, and nondestructive measurements. Recent advances in Raman imaging (RI) have greatly progressed lipidomic analysis, such as lipid droplet content, lipid phenotype, fatty acid composition, spatial distribution and drug treatment res...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
Publication date: Available online 18 October 2018Source: Journal of Molecular LiquidsAuthor(s): Mostafa Zamani, Ehsan Naderi, Mozhgan Aghajanzadeh, Mahmoud Naseri, Ali Sharafi, Hossein DanafarAbstractThe present paper aimed to synthesize, using thermal-treatment method, a variety of Co1-XZnxFe2O4-based nanocarriers (NCs) as Dual-controlled and targeted drug delivery systems (DDS) and provide a new structure as NCs suitable for the loading and pH-responsive characteristics of the chemotherapeutic curcumin (CUR). To study the structure, surface morphology, surface charge and magnetic properties of NCs, X-ray diffraction (XR...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
This study examined the role of H2S in drug resistance in liver cancer cells.Materials and methodsHuman primary hepatocellular carcinoma cell line (HepG2) and doxorubicin (Dox)-resistant cells were used in this study. Cell survival was analyzed by MTT, Annexin V-FITC/propidium iodide staining and clonogenic assay. Western blotting was used for analysis of protein expression, and immunoprecipitation was used to determine interactions of LXR/RXR.Key findingsThe expression of H2S-generating enzyme cystathionine gamma-lyase (CSE) was inhibited by doxorubicin treatment in HepG2 cells, and H2S sensitized Dox-inhibited cell survi...
Source: Life Sciences - Category: Biology Source Type: research
A Houston hospital is replacing the surgical director of its renowned heart transplant programs with two veteran transplant surgeons and a veteran transplant program executive
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
This study was based on the fact that, overall mass, charge and size of a protein changes after interaction with charged ligands such as metal ions, which affects the electrophoretic movement of the analyte protein under the influence of electroosmotic flow. This alteration in electrophoretic mobility of the analyte is proportional to the strength of interaction between the two species and is utilized to calculate the binding results. The mobility ratio (R) of an EOF marker (injected in same run) and the analyte enzyme was determined and the binding result was expressed as the normalized difference of the mobility ratios o...
Source: Microchemical Journal - Category: Chemistry Source Type: research
Publication date: Available online 18 October 2018Source: Genes &DiseasesAuthor(s): Xingxing Zang
Source: Genes and Diseases - Category: Genetics & Stem Cells Source Type: research
A Houston hospital is replacing the surgical director of its renowned heart transplant programs with two veteran transplant surgeons and a veteran transplant program executive
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
Switching to a better, lower fat diet can reduce the risk of death by 20 percent for colorectal cancer patients, a new American Cancer Society study found. Western diets high in fat raise death risks.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
An Oregon teenager’s innovation could change the way doctors treat pancreatic cancer, a deadly form of the disease that has just a 7% five-year survival rate. Rishab Jain, a 13-year-old from Stoller Middle School in Portland, on Tuesday won the Discovery Education 3M Young Scientist Challenge with an algorithm that uses machine learning to help doctors zero in on the pancreas during cancer treatment. Doing so can be difficult, since the pancreas is often obscured by other organs, and since breathing and other bodily processes can cause it to move around the abdominal area. As a result, doctors sometimes need to deplo...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Cancer healthytime onetime Source Type: news
In conclusion, our data show that clonal hematopoiesis emerges in the majority of patients with AA, including children and young adults, can be detected early in disease, and has a mutational spectrum largely distinct from MDS. Our results highlight that in the absence of morphologic features of myelodysplasia, the presence of clonal hematopoiesis with somatic mutations cannot be used to distinguish MDS from AA. Future longitudinal studies of clonal hematopoiesis in AA will help to explain differences in patients’ disease course, and will enable personalized treatment approaches in AA.Citation Format: Daria V. Babush...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Molecular and Cellular Biology Source Type: research
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