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Genetic features of myelodysplastic syndrome and aplastic anemia in pediatric and young adult patients.

This study shows that while any single specific bone marrow failure/myelodysplastic syndrome genetic disorder is rare, screening for these disorders in aggregate identifies a significant subset of patients with inherited bone marrow failure/myelodysplastic syndrome. PMID: 27418648 [PubMed - in process]
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research

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Aneurysms of the renal arteries are rare, probably under-diagnosed, with an incidence estimated at 0.01%. A size exceeding 20mm and the presence of symptoms such as hypertension represent a therapeutic indication for most authors. Endovascular techniques are used more and more to treat proximal lesions and auto-transplantation is the technique of reference for intra-parenchymatous lesions. However, most hilar, non-intra-parenchymatous lesions can be treated in situ without cooling and with a reasonable clamping time.
Source: Annals of Vascular Surgery - Category: Surgery Authors: Tags: Abstracts Presented to the French Vascular Surgery Society Source Type: research
The objective of this work was to study the mid-term results of the angioplast y of the renal artery on transplanted kidneys.
Source: Annals of Vascular Surgery - Category: Surgery Authors: Tags: Abstracts Presented to the French Vascular Surgery Society Source Type: research
The breadth of a health insurance plan's network typically dictates the level of access that a consumer will have to primary care physicians, specialists, and other types of health care providers. Thus, the comprehensiveness of plan networks —including whether consumers have access to in-network cancer centers—is a critical component of quality health insurance. In response to increased health care costs and pressure to keep premiums down, health plans have begun to adopt “narrow network” plans. A narrow network plan has been ty pically defined as a plan with a more limited number of providers as co...
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: The Profession Source Type: research
Postmastectomy radiation therapy (PMRT) generally improves locoregional control and overall survival in patients with pathologic lymph node-positive breast cancer, as evidenced by meta-analyses of randomized trials (1). Nevertheless, controversy persists regarding whether PMRT is indicated for all such patients, especially those with clinical T1-T3N1 who receive neoadjuvant chemotherapy (NAC) with a complete pathologic response in the involved axillary lymph nodes (ypN0). For such patients, the current standard recommendation is to offer entry into clinical trials comparing regional nodal irradiation (RNI) versus no RNI (2...
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Clinical Investigation Source Type: research
To the Editor: We read with interest the recently published report by Vashistha et  al, “Radical cystectomy compared to combined modality treatment for muscle-invasive bladder cancer: A systemic review and meta-analysis” (1). The authors searched 7 databases, found 19 studies evaluating 12,380 subjects, and finally selected 8 studies encompassing 9554 subjects eligible for m eta-analysis. They reported no difference in overall survival at 5 years or progression-free survival at 10 years within this cohort of 9554 patients.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Comment Source Type: research
In this issue of Oncology Scan, the Gynecologic Cancer editors discuss publications of molecular analysis of primary cervical cancer as part of the Cancer Genome Atlas project and advancements in 3-dimensional (3D) brachytherapy (BT) for cervical cancer. The genomic study highlights a specific type of cervical cancer classified as keratin-low, which has lower survival with surgery, and further work needs to be done to determine whether this difference in outcome holds true for patients treated with definitive chemoradiation therapy.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Feature Source Type: research
We read with interest the recent Red Journal article “Radical Prostatectomy Versus Radiation and Androgen Deprivation Therapy for Clinically Localized Prostate Cancer: How Good Is the Evidence?” by Roach et al (1). This was a thoughtful and critical analysis of the complex literature relating to irradiation versus prostatectomy in men with locali zed prostate cancer. Overall, the authors assigned low reliability scores to many of the studies evaluated, citing an inadequate (or unreported) duration of androgen deprivation therapy (ADT) with radiation therapy for intermediate- or high-risk disease, unadjuste...
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Two Perspectives on the ProtecT Trial in Localized Prostate Cancer Source Type: research
The landmark Prostate Testing for Cancer and Treatment (ProtecT) study was published in September 2016 (1).  This is the first randomized trial to answer the question of which treatment among surgery, radiation therapy, and active surveillance is best for low-risk prostate cancer. The fact that the authors were able to perform and complete this study deserves immense credit.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Two Perspectives on the ProtecT Trial in Localized Prostate Cancer Source Type: research
This report presents a randomised controlled trial of a mindfulness-based intervention during chemotherapy and suggests that care is needed in employing mindfulness-based interventions in acute health treatment contexts.
Source: Mindfulness - Category: Psychiatry & Psychology Source Type: research
In conclusion, our data show that clonal hematopoiesis emerges in the majority of patients with AA, including children and young adults, can be detected early in disease, and has a mutational spectrum largely distinct from MDS. Our results highlight that in the absence of morphologic features of myelodysplasia, the presence of clonal hematopoiesis with somatic mutations cannot be used to distinguish MDS from AA. Future longitudinal studies of clonal hematopoiesis in AA will help to explain differences in patients’ disease course, and will enable personalized treatment approaches in AA.Citation Format: Daria V. Babush...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Molecular and Cellular Biology Source Type: research
More News: Anemia | Aplastic Anemia | Cancer | Cancer & Oncology | Cancer in Adolescents | Cancer in Young Adults | Children | Genetics | Myelodysplastic Syndrome | Pediatrics | Study | Transplants