MassDevice.com +5 | The top 5 medtech stories for October 4, 2016

Say hello to MassDevice +5, a bite-sized view of the top five medtech stories of the day. This feature of MassDevice.com’s coverage highlights our 5 biggest and most influential stories from the day’s news to make sure you’re up to date on the headlines that continue to shape the medical device industry. Get this in your inbox everyday by subscribing to our newsletters.   5. FDA approves Valencia’s eCoin neurostim trial Valencia Technologies said today it won investigational device exemption approval from the FDA to begin a trial of its eCoin neurostimulator for treating drug-resistant hypertension. The company is slated to pick up 300 patients on at least 3 antihypertensive drugs for a trial of the coin-sized device, which is designed to be placed in the forearm during a short in-office procedure under local anesthesia. Read more 4. BD, Apax Partners close Vyaire respiratory JV deal, tap ex-Tornier chief Mowry for CEO Becton Dickinson &Co. said today it finalized the launch of a respiratory solutions joint venture with Apax Partners under the Vyaire Medical brand. The deal, which the companies announced in March, will put a controlling 50.1% of BD’s respiratory solutions business under the control of the private equity shop, and put former Tornier chief exec &ex-Wright Medical COO Dave Mowry in the corner office of the new JV. Read more 3. FDA approves St. Jude Medical’s BurstDR spinal cord stimulation for chr...
Source: Mass Device - Category: Medical Equipment Authors: Tags: News Well Plus 5 Source Type: news

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Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
The hypothalamus–pituitary–adrenal (HPA) axis acts to release cortisol into the blood stream, as cortisol calls the body into action to combat stress. When high amounts of cortisol interact with the hypothalamus, the HPA axis will slow down its activity. The amygdala detects stress, while the prefrontal cortex regulates our reactions to stress. Source: Bezdek K and Telzer E (2017) Have No Fear, the Brain is Here! How Your Brain Responds to Stress. Front. Young Minds. 5:71. doi: 10.3389/frym.2017.00071 _______ [Editor’s note: Continued from yesterday’s Exploring the human brain and how it responds to...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Education & Lifelong Learning Health & Wellness #WorldHealthDay brain burnout cognition Cortisol GAS General Adaptation Syndrome homeostasis memory neurobiology neurological exhaustion Stress Source Type: blogs
Abstract Spinal cord injury (SCI) can have profound effects on the autonomic and cardiovascular systems, notably with injuries above high-thoracic levels that result in the development of autonomic dysreflexia (AD) characterized by volatile hypertension in response to exaggerated sympathetic reflexes triggered by afferent stimulation below the injury level. Pathophysiological changes associated with the development of AD include sprouting of both nociceptive afferents and ascending propriospinal 'relay' neurons below the injury, as well as dynamic changes in synaptic inputs onto sympathetic preganglionic neurons. ...
Source: Experimental Neurology - Category: Neurology Authors: Tags: Exp Neurol Source Type: research
In this study, we analyzed FGF21 levels and alterations in the expression of genes encoding components of the FGF21-responsive molecular machinery in adipose tissue from aged individuals so as to ascertain whether altered FGF21 responsiveness that develops with aging jeopardizes human health and/or accelerates metabolic disturbances associated with aging. We studied a cohort of 28 healthy elderly individuals (≥70 years) with no overt signs of metabolic or other pathologies and compared them with a cohort of 35 young healthy controls (≤40 years). Serum FGF21 levels were significantly increased in elderly indiv...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Authors: LaVela SL, Etingen B, Miskevics S, Heinemann AW Abstract OBJECTIVE: To examine variables associated with satisfaction with life (SWL) in individuals with a spinal cord injury (SCI). DESIGN: Cross-sectional, national survey to assess SWL, demographic and injury characteristics, health care utilization, chronic conditions (obesity, diabetes, heart problems, lung problems, hypertension, high cholesterol), symptoms (poor sleep, pain, depression), social support, grief/loss, and independence. SETTING/PARTICIPANTS: Community-dwelling Veterans with SCI. Outcome Measures/Analyses: Bivariate analyses were c...
Source: Journal of Spinal Cord Medicine - Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research
Aim and objectivesTo predict the risk factors related to newly diagnosed psychiatric disorders resulting from spinal cord injuries (SCIs). BackgroundSCIs are a common result of devastating accidents; they can have an essential negative impact on the psychological health of those so afflicted. Psychiatric disorders commonly occur worldwide and are often associated with pain and disability; however, few studies have investigated the risk factors of psychiatric disorders among persons with SCIs. DesignA retrospective cohort study design with data obtained from the Taiwan Health Insurance Research Database (THIRD). THIRD invol...
Source: Journal of Clinical Nursing - Category: Nursing Authors: Tags: ORIGINAL ARTICLE Source Type: research
Abstract AimTo predict the risk factors related to newly diagnosed psychiatric disorders resulting from spinal cord injuries (SCIs) BackgroundSCIs are a common result of devastating accidents; they can have an essential negative impact on the psychological health of those so afflicted. Psychiatric disorders commonly occur worldwide, and are often associated with pain and disability; however, few studies have investigated the risk factors of psychiatric disorders among persons with SCIs. DesignA retrospective cohort study design, with data obtained from the Taiwan Health Insurance Research Database (THIRD). THIRD involves t...
Source: Journal of Clinical Nursing - Category: Nursing Authors: Tags: Original Article Source Type: research
Conclusion Hyperexcitability of T5 and T6 sympathetic preganglionic fibers appears to be the main etiology of LPR. SNEPI can reduce LES relaxation and improve blood flow to the mucosa, thereby increasing the stability of the vagus reflex and laryngopharyngeal mucosal defense factors. To the best of our knowledge, this case represents the first report of a patient with LPR refractory to PPIs who was successfully treated with SNEPI alone. SNEPI can be considered as an alternative to anti-reflux procedures. References 1. Vakil N, van Zanten SV, Kahrilas P, et al. Global Consensus Group. The Montreal definition and classificat...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Case Report Current Issue Medical Issues Neurologic Systems and Symptoms Neurology antireflux procedure autonomic regulation laryngopharyngeal reflux refractory Sympathetic nerve entrapment point injection Source Type: research
This study is the first CAR T-cell trial to infuse patients with an even mixture of two types of T cells (helper and killer cells, which work together to kill cancer). With the assurance that each patient gets the same mixture of cells, the researchers were able to come to conclusions about the effects of administering different doses of cells. In 27 of 29 participants whose responses were evaluated a few weeks after the infusion, a high-sensitivity test could detect no trace of their cancer in their bone marrow. The CAR T cells eliminated cancers anywhere in the body they appeared. Of the two participants who did n...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusion: In conclusion, these data illustrate important interrelationships between secondary complications following SCI, as well as raise the possibility of neuropathic pain (versus nociceptive pain) as a novel and emerging risk factor for CVD.Neuroepidemiology 2015;44:130-137
Source: Neuroepidemiology - Category: Epidemiology Source Type: research
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