Association between first‐line monotherapy with sulfonylurea versus metformin and risk of all‐cause mortality and cardiovascular events: a retrospective, observational study

ConclusionsAll‐cause mortality was significantly increased in patients prescribed sulfonylurea compared with metformin monotherapy. Whilst residual confounding and confounding by indication may remain, this study indicates that first‐line treatment with sulfonylurea monotherapy should be reconsidered.

Source: Diabetes, Obesity and Metabolism - April 1, 2014 Category: Endocrinology Authors: C.Ll. Morgan, J. Mukherjee, S. Jenkins‐Jones, S.E. Holden, C.J. Currie Tags: ORIGINAL PAPER Source Type: research