Cardiomyocyte Apoptosis Contributes to Pathogenesis of Cirrhotic Cardiomyopathy in Bile Duct-Ligated Mice

Conclusion:A net pro-apoptotic balance exists in BDL hearts, mainly mediated by activation of the extrinsic pathway, and abrogation of apoptosis improved contractility. These results suggest that apoptosis contributes to depressed cardiac contractility in a murine model of cirrhotic cardiomyopathy.

Source: Clinical Science - April 9, 2014 Category: Biomedical Science Authors: S Nam, H Liu, J Z. Wang, A Y Feng, G Chu, N Merchant, S S Lee Source Type: research