Increase of cortical cerebral blood flow and further cerebral microcirculatory effects of Serelaxin in a sheep model

In conclusion, the injection of a high dose of Serelaxin exerts quick effects on the cerebral microcirculation. Therefore, Serelaxin might be suitable to improve cortical microcirculation and exert neuroprotective effects in clinically relevant scenarios that involve cortical hypoperfusion. These findings need to be confirmed in relevant experimental settings involving cerebral cortical hypoperfusion and can possibly be translated into clinical practice.

Source: AJP: Heart and Circulatory Physiology - August 31, 2016 Category: Cardiology Authors: Bischoff, S. J., Schmidt, M., Lehmann, T., Irintchev, A., Schubert, H., Jung, C., Schwab, M., Huber, O., Matziolis, G., Schiffner, R. Tags: VASCULAR BIOLOGY AND MICROCIRCULATION Source Type: research