{alpha}v{beta}6 Integrin Activates Androgen Receptor

In conclusion, we show that αvβ6 expression is required for prostate cancer progression, including castrate-resistant prostate cancer; mechanistically, by promoting activation of JNK1, the αvβ6 integrin causes androgen receptor–increased activity in the absence of androgen and consequent upregulation of survivin. These preclinical results pave the way for further clinical development of αvβ6 antagonists for prostate cancer therapy. Cancer Res; 76(17); 5163–74. ©2016 AACR.

Source: Cancer Research - August 30, 2016 Category: Cancer & Oncology Authors: Lu, H., Wang, T., Li, J., Fedele, C., Liu, Q., Zhang, J., Jiang, Z., Jain, D., Iozzo, R. V., Violette, S. M., Weinreb, P. H., Davis, R. J., Gioeli, D., FitzGerald, T. J., Altieri, D. C., Languino, L. R. Tags: Tumor and Stem Cell Biology Source Type: research