Genetics of Cardiovascular Diseases. Lessons learned from a decade of genomics research in Iceland.

Genetics of Cardiovascular Diseases. Lessons learned from a decade of genomics research in Iceland. Scand Cardiovasc J. 2016 Aug 30;:1-21 Authors: Arnar DO, Andersen K, Thorgeirsson G Abstract In the past ten years large scale genotyping has led to discoveries of sequence variants that confer risk of many common and complex diseases. Due to pioneering work done, in large part, at deCODE genetics in Reykjavik, discoveries from Iceland have contributed substantially to key advances in population genetics. In cardiovascular medicine a number of discoveries have been made, uncovering sequence variants that are associated with disorders such as coronary artery disease, atrial fibrillation, sick sinus syndrome, peripheral vascular disease, aortic aneurysm and ischemic stroke. Thus, a wealth of genetic data has been accumulated in cardiology and has enchanced our understanding of a number of diseases. In many cases these findings offer new mechanistic clues into the pathophysiology of complex cardiovascular diseases and may point towards novel therapeutic approaches in drug therapy. The next important step is to to begin to transform these findings into practical clinical knowledge with the aim of improving the delivery of cardiovascular health care. PMID: 27572422 [PubMed - as supplied by publisher]
Source: Scandinavian Cardiovascular Journal - Category: Cardiology Tags: Scand Cardiovasc J Source Type: research