NTCP modeling analysis of acute hematologic toxicity in whole pelvic radiation therapy for gynecologic malignancies – A dosimetric comparison of IMRT and spot-scanning proton therapy (SSPT)

Whole pelvic radiation therapy (WPRT) plays an important role in the treatment of gynecologic cancers, especially cervical and endometrial cancers. Conventional WPRT contains approximately 40% of the total body bone marrow (BM) and results in hematologic toxicity (HT) [1]. Concurrent chemoradiotherapy (CCRT) is used to improve treatment outcome. However, adding chemotherapy increases the risk of severe HT. Severe HT is critical issue because it disturbs the execution of treatment on schedule such as interruptions of radiotherapy and holds or stops chemotherapy [2].

Source: Physica Medica: European Journal of Medical Physics - August 25, 2016 Category: Journals (General) Authors: Takaaki Yoshimura, Rumiko Kinoshita, Shunsuke Onodera, Chie Toramatsu, Ryusuke Suzuki, Yoichi M. Ito, Seishin Takao, Taeko Matsuura, Yuka Matsuzaki, Kikuo Umegaki, Hiroki Shirato, Shinichi Shimizu Tags: Original paper Source Type: research