Questionable Testing Common After Ovarian Cancer Therapy Questionable Testing Common After Ovarian Cancer Therapy

Despite evidence that cancer antigen 125 (CA-125) tests and CT scans for surveillance in ovarian cancer patients are not beneficial after treatment, the practice continues, according to a multicenter study.Reuters Health Information
Source: Medscape Pathology Headlines - Category: Pathology Tags: Hematology-Oncology News Source Type: news

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Authors: Wu D, Yu X, Wang J, Hui X, Zhang Y, Cai Y, Ren M, Guo M, Zhao F, Dou J Abstract Tumor vaccines offer a number of advantages for cancer treatment. In the study, the vaccination with cancer stem cells (CSCs) with high expression of the type I receptor tyrosine kinase-like orphan receptor (ROR1) was evaluated in a murine model for the vaccine's immunogenicity and protective efficacy against epithelial ovarian carcinoma (EOC). CD117+CD44+ CSCs were isolated from human EOC HO8910 cell line using a magnetic-activated cell sorting system; murine ID8 EOC suspension sphere cells, which are collectively known as can...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Condition:   Ovarian Cancer Intervention:   Drug: Anlotinib Sponsor:   Second Affiliated Hospital, School of Medicine, Zhejiang University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Fallopian Tube Cancer;   Fallopian Tube Carcinosarcoma;   Fallopian Tube Clear Cell Adenocarcinoma;   Fallopian Tube Endometrioid Adenocarcinoma;   High Grade Fallopian Tube Serous Adenocarcinoma;   High Grade Ovarian Serous Adenocarcinoma;   Ovarian Carcinosarcoma;   Ovarian Clear Cell Adenocarcinoma;   Ovarian Endometrioid Adenocarcinoma;   Primary Peritoneal Serous Adenocarcinoma;   Recurrent Endometrial&...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Contributor : Joan SeoaneSeries Type : Expression profiling by arrayOrganism : Mus musculusLIF has an important role in immunosupression in different scenarios, such as embryo implantation in the uterus, autoimmune disease or organ transplantation. We decided to study the role of LIF on the immune response to cancer. We found that tumors expressing high levels of LIF promote an immune-tolerant microenvironment precluding the anti-tumor immune response.To establish the effect of LIF on tumor-associated myeloid cells (TAMCs), we used a syngeneic ovarian tumor model (ID8 cell line). We treated animals bearing tumors with anti...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
Conditions:   Ovarian Cancer Stage IIIC;   Fallopian Tube Cancer Stage IIIC;   Fallopian Tube Cancer Stage IV;   Ovarian Cancer Stage IV Intervention:   Procedure: Blood sample collection Sponsors:   Centre Oscar Lambret;   Institut National de la Santé Et de la Recherche Médicale, France Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
A study of genetic testing in ovarian and breast cancer patients found substantial disparities in testing rates for ovarian cancer patients.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
Publication date: Available online 19 April 2019Source: Seminars in Cancer BiologyAuthor(s): Lingzhi Li, Zhuoyu Bi, Priya Wadgaonkar, Yongju Lu, Qian Zhang, Yao Fu, Chitra Thakur, Li Wang, Fei ChenAbstractAt present, the belief that genetic mutations control every aspect of tumorigenesis is still very popular. Even for the highly debated “bad luck” theory of cancers, it ascertained that random mutation of genes during the self-renewal of somatic stem cells is responsible for cancer initiation. Logically, most of the new therapeutic strategies so far, from molecular targeting to precision medicine or personalize...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
A 19‑miRNA Support Vector Machine classifier and a 6‑miRNA risk score system designed for ovarian cancer patients. Oncol Rep. 2019 Apr 10;: Authors: Dong J, Xu M Abstract Ovarian cancer (OC) is the most common gynecologic malignancy with high incidence and mortality. The present study aimed to develop approaches for determining the recurrence type and identify potential miRNA markers for OC prognosis. The miRNA expression profile of OC (the training set, including 390 samples with recurrence information) was downloaded from The Cancer Genome Atlas database. The validation sets GSE25204 and GSE27290...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Dynamic contrast enhanced‑magnetic resonance imaging for the early evaluation of the response to docetaxel in rats with epithelial ovarian cancer. Oncol Rep. 2019 Apr 17;: Authors: Yuan SJ, Qiao TK, Qiang JW, Cai SQ Abstract Dynamic contrast enhanced‑magnetic resonance imaging (DCE‑MRI) contributes to the early detection and prediction of responses to chemotherapy in cancer. The aim of the present study was to investigate the feasibility of quantitative DCE‑MRI parameters for noninvasively predicting the early response to DTX in epithelial ovarian cancer (EOC). In the present study, using 7,12...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Authors: Zhao L, Shou H, Chen L, Gao W, Fang C, Zhang P Abstract Epigenetic modifications are closely related to oncogene activation and tumor suppressor gene inactivation. The aim of this study was to determine the effects of ginsenoside Rg3 on epigenetic modification in ovarian cancer cells. Cell proliferation, metastasis, invasion and apoptosis were respectively determined using Cell Counting Kit‑8 (CCK‑8), wound healing, Transwell and flow cytometric assays. Methylation levels were determined using methylation specific PCR (MSP). Related‑factor expression was detected by conducting real‑time‑qPCR (RT...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
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