Questionable Testing Common After Ovarian Cancer Therapy Questionable Testing Common After Ovarian Cancer Therapy

Despite evidence that cancer antigen 125 (CA-125) tests and CT scans for surveillance in ovarian cancer patients are not beneficial after treatment, the practice continues, according to a multicenter study.Reuters Health Information
Source: Medscape Pathology Headlines - Category: Pathology Tags: Hematology-Oncology News Source Type: news

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MiR‑381 regulates cell motility, growth and colony formation through PIK3CA in endometriosis‑associated clear cell and endometrioid ovarian cancer. Oncol Rep. 2018 Oct 09;: Authors: Hsu CY, Hsieh TH, Er TK, Chen HS, Tsai CC, Tsai EM Abstract Ovarian cancer is the one of the most lethal gynecological cancer types. MicroRNAs (miRs) are noncoding RNAs that modulate the translation of their target mRNAs via binding to a complementary sequence in the target 3' untranslated region, and the dysregulation of certain miRs has been demonstrated to contribute to cancer progression. In this regard, the current...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
SMAD specific E3 ubiquitin protein ligase 1 promotes ovarian cancer cell migration and invasion via the activation of the RhoA/ROCK signaling pathway. Oncol Rep. 2018 Oct 31;: Authors: Wang W, Du H, Liu H, Hu F, Liu G Abstract SMAD specific E3 ubiquitin protein ligase 1 (SMURF1) serves a pivotal role in a variety of pathological processes and in tumor cell migration and invasion; however, its functional mechanism in ovarian cancer (OC) remains unknown. Previously, we observed overexpression of SMURF1 in OC tissues. In the present study, the role of SMURF1 in OC metastasis was investigated. Th...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Authors: Bersini S, Miermont A, Pavesi A, Kamm RD, Thiery JP, Moretti M, Adriani G Abstract The reciprocal interaction between circulating tumor cells (CTCs) and tissue-specific cells is influential for the progression of metastases. In particular, the process of extravasation relies on the complex cross-talk between cancer cells and other cellular players such as the endothelium and the secondary tissue. However, most in vitro studies only focus on one heterotypic cell-cell interaction and often lack of physiological relevance. In this project, we investigated both CTC-endothelium and CTC-secondary site interactio...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Ghafoor A, Thomas A, Hassan R PMID: 30546824 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
In conclusion, although imaging of fresh samples at 37°C is the best condition for both probes, successful imaging with gGlu-HMRG could be achieved even at room temperature with thawed samples. We demonstrate that temperature regulation and tissue handling of resected tissue are two pitfalls that may influence ex vivo imaging signals with enzyme-activatable fluorescent probes. PMID: 30542517 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
This study aimed to evaluate the budget impact of niraparib and olaparib in patients with platinum-sensitive, recurrent ovarian cancer from a US third party payer perspective. MATERIALS AND METHODS: A budget impact model was constructed to assess the additional per member per month (PMPM) costs associated with the introduction of niraparib and olaparib, two poly ADP ribose polymerase (PARP) inhibitors recently approved to be used in platinum-sensitive, recurrent ovarian cancer patients with and without a BRCA mutation. The model assessed both pharmacy costs and medical costs. Pharmacy costs included adjusted drug costs...
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
Johnson&Johnson says its product is safe. But asbestos, a carcinogen that can exist underground near talc, was a concern inside the company for decades.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Asbestos Hazardous and Toxic Substances Product Tests Ovarian Cancer Suits and Litigation (Civil) Mesothelioma Cosmetics and Toiletries Research Johnson & Food and Drug Administration Source Type: news
Investors responded negatively to an extensive report Friday that Johnson &Johnson knew for decades that its iconic baby powder could be contaminated with asbestos fibers but failed to warn the public or inform regulators. Shares of Johnson &Johnson stock dropped by 10 percent Friday, its worst loss in almost two decades, dealing the company a serious financial setback. Reuters News Service detailed internal documents, company memos and extensive conversations that contradicted previous claims by Johnson &Johnson that its Shower to Shower and Baby Powder products were beyond reproach. Johnson &Johnson alrea...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Publication date: Available online 13 December 2018Source: Diagnostic and Interventional ImagingAuthor(s): S. Nougaret, M. Tardieu, H.A. Vargas, C. Reinhold, S. Vande Perre, N. Bonanno, E. Sala, I. Thomassin-NaggaraAbstractTumor heterogeneity in ovarian cancer has been reported at the histological and genetic levels and is associated with adverse clinical outcomes. Tumor evaluation using standard computed tomography or magnetic resonance imaging techniques does not account for the intra- or inter-tumoral heterogeneity in advanced ovarian cancer with peritoneal carcinomatosis. As such, computational approaches in assessing ...
Source: Diagnostic and Interventional Imaging - Category: Radiology Source Type: research
(CBS News/CBS Local)– Johnson &Johnson has for decades known its raw talc and finished powders at times tested positive for small quantities of asbestos, with the company’s doctors and lawyers vexed by the findings but failing to alert regulators or consumers, according to a Reuters story published Friday. J&J stock — up 6 percent for the year — plunged 11 percent on news of the report, based on memos, internal documents and confidential memos that the maker of Johnson’s Baby Powder had been compelled to share with attorneys for some 11,700 plaintiffs who claim the company’...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Offbeat baby powder Johnson & Johnson Local TV talkers Source Type: news
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