123I ‐2β‐carbomethoxy‐3β‐(4‐iodophenyl)‐N‐(3‐fluoropropyl) nortropane single photon emission computed tomography and 123I‐metaiodobenzylguanidine myocardial scintigraphy in differentiating dementia with lewy bodies from other dementias: A comparative study

ObjectiveTo compare the diagnostic value of striatal 123I‐2β‐carbomethoxy‐3β‐(4‐iodophenyl)‐N‐(3‐fluoropropyl) nortropane (123I‐FP‐CIT) single photon emission computed tomography (SPECT) and 123I‐metaiodobenzylguanidine (123I‐MIBG) myocardial scintigraphy in differentiating dementia with Lewy bodies (DLB) from other dementia types. MethodsThis prospective longitudinal study included 30 patients with a clinical diagnosis of DLB and 29 patients with non‐DLB dementia (Alzheimer disease, n = 16; behavioral variant frontotemporal dementia, n = 13). All patients underwent 123I‐FP‐CIT SPECT and 123I‐MIBG myocardial scintigraphy within a few weeks of clinical diagnosis. All diagnoses at each center were agreed upon by the local clinician and an independent expert, both unaware of imaging data, and re‐evaluated after 12 months. Each image was visually classified as either normal or abnormal by 3 independent nuclear physicians blinded to patients' clinical data. ResultsOverall, sensitivity and specificity to DLB were respectively 93% and 100% for 123I‐MIBG myocardial scintigraphy, and 90% and 76% for 123I‐FP‐CIT SPECT. Lower specificity of striatal compared to myocardial imaging was due to decreased 123I‐FP‐CIT uptake in 7 non‐DLB subjects (3 with concomitant parkinsonism) who had normal 123I‐MIBG myocardial uptake. Notably, in our non‐DLB group, myocardial imaging gave no false‐positive readings even in those subjects (n ...
Source: Annals of Neurology - Category: Neurology Authors: Tags: Research Article Source Type: research