Cancer-fighting therapy shows promise as treatment to speed up wound healing

A type of targeted therapy that has shown promising results treating advanced melanoma could also be used to help speed up how the skin repairs itself from injury, UCLA researchers have found, providing a potential new way to accelerate healing of acute and chronic wounds. In the United States alone, chronic wounds affect more than 6.5 million people and an estimated $50 billion is spent annually treating these conditions. Many areas of medicine — from improving recovery times after surgery to reducing skin-related secondary effects of cancer treatments and other diseases — can benefit from speeding up the skin’s healing process. Aiming to meet this urgent and unmet need, the UCLA researchers investigated a new class of cancer therapy called BRAF inhibitors. These drugs work by blocking a mutated gene in melanoma, which rapidly shrinks the tumor. This can set off a cellular cascade in other skin cells in a process called paradoxical MAPK activation, which can lead to a variety of skin-related side effects, said Dr. Antoni Ribas, director of the UCLA Jonsson Comprehensive Cancer Center Tumor Immunology Program and senior author of the study. “We set out to take advantage of our mechanistic understanding of these drugs and see if we could turn a side effect into a potentially beneficial effect,” Ribas said. “These agents have great potential to be used to develop topical treatments to greatly accelerate wound healing.” The three-year st...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
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Source: Experimental Gerontology - Category: Geriatrics Authors: Tags: Exp Gerontol Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
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Source: Acta Reumatologica Portuguesa - Category: Rheumatology Authors: Tags: Acta Reumatol Port Source Type: research
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