Cancer-fighting therapy shows promise as treatment to speed up wound healing
A type of targeted therapy that has shown promising results treating advanced melanoma could also be used to help speed up how the skin repairs itself from injury, UCLA researchers have found, providing a potential new way to accelerate healing of acute and chronic wounds. In the United States alone, chronic wounds affect more than 6.5 million people and an estimated $50 billion is spent annually treating these conditions. Many areas of medicine — from improving recovery times after surgery to reducing skin-related secondary effects of cancer treatments and other diseases — can benefit from speeding up the skin’s healing process. Aiming to meet this urgent and unmet need, the UCLA researchers investigated a new class of cancer therapy called BRAF inhibitors. These drugs work by blocking a mutated gene in melanoma, which rapidly shrinks the tumor. This can set off a cellular cascade in other skin cells in a process called paradoxical MAPK activation, which can lead to a variety of skin-related side effects, said Dr. Antoni Ribas, director of the UCLA Jonsson Comprehensive Cancer Center Tumor Immunology Program and senior author of the study. “We set out to take advantage of our mechanistic understanding of these drugs and see if we could turn a side effect into a potentially beneficial effect,” Ribas said. “These agents have great potential to be used to develop topical treatments to greatly accelerate wound healing.” The three-year st...
A new study inCancer Management and Research found a correlation between the age of patients with papillary thyroid cancer and lymph node positivity.
Measures of frailty and comorbidity failed to offer predictive information regarding complications in patients with bladder cancer undergoing radical cystectomy.
Time to progression ratio in cancer patients enrolled in early phase clinical trials: time for new guidelines?, Published online: 17 October 2018; doi:10.1038/s41416-018-0245-0Time to progression ratio in cancer patients enrolled in early phase clinical trials: time for new guidelines?
Waist circumference and risk of 23 site-specific cancers: a population-based cohort study of Korean adults, Published online: 17 October 2018; doi:10.1038/s41416-018-0214-7Waist circumference and risk of 23 site-specific cancers: a population-based cohort study of Korean adults
Combinations of BRAF inhibitor and anti-PD-1/PD-L1 antibody improve survival and tumour immunity in an immunocompetent model of orthotopic murine anaplastic thyroid cancer, Published online: 17 October 2018; doi:10.1038/s41416-018-0296-2Combinations of BRAF inhibitor and anti-PD-1/PD-L1 antibody improve survival and tumour immunity in an immunocompetent model of orthotopic murine anaplastic thyroid cancer
CD24 regulates cancer stem cell (CSC)-like traits and a panel of CSC-related molecules serves as a non-invasive urinary biomarker for the detection of bladder cancer, Published online: 17 October 2018; doi:10.1038/s41416-018-0291-7CD24 regulates cancer stem cell (CSC)-like traits and a panel of CSC-related molecules serves as a non-invasive urinary biomarker for the detection of bladder cancer
Breast osteoblast-like cells: a new biomarker for the management of breast cancer, Published online: 17 October 2018; doi:10.1038/s41416-018-0255-yBreast osteoblast-like cells: a new biomarker for the management of breast cancer
Abstract Longer lifespan is accompanied by a larger number of chronic diseases among older adults. Because of a growing proportion of older adults in the U.S., this brings the problem of age-related morbidity to the forefront as a major contributor to rising medical expenditures. We evaluated 15-year time trends (from 1998 to 2013) in the prevalence of 48 acute and chronic non-cancer diseases and cancers in older U.S. adults aged 65+ and estimated the annual percentage changes of these prevalence trends using SEER-Medicare and HRS-Medicare data. We found that age-adjusted prevalence of cancers of kidney, pancreas,...
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
CONCLUSIONS: Comorbid conditions of RA are common and associated with more active and severe disease and functional impairment. Comorbidities should be detected and treated earlier to reduce its negative impact on outcome in RA. PMID: 27926914 [PubMed - as supplied by publisher]