Inhibition of diethylnitrosamine-induced liver cancer in rats by Rhizoma paridis saponin

Publication date: Available online 14 July 2016 Source:Environmental Toxicology and Pharmacology Author(s): Jing Liu, Shuli Man, Jing Li, Yang Zhang, Xin Meng, Wenyuan Gao Rhizoma Paridis saponin (RPS) had been regarded as the main active components responsible for the anti-tumor effects of the herb Paris polyphylla var. yunnanensis (Franch.) Hand.-Mazz. In the present research, we set up a rat model of diethylnitrosamine (DEN) induced hepatoma to evaluate antitumor effect of RPS. After 20 weeks treatment, rats were sacrificed to perform histopathological examinations, liver function tests, oxidative stress assays and so forth. As a result, DEN-induced hepatoma formation. RPS alleviated levels of liver injury through inhibiting liver tissues of malondialdehyde (MDA) and nitric oxide (NO) formation, increasing superoxide dismutases (SOD) production, and up-regulating expression of GST-α/μ/π in DEN-induced rats. All in all, RPS would be a potent agent inhibiting chemically induced liver cancer in the prospective application. Graphical abstract
Source: Environmental Toxicology and Pharmacology - Category: Environmental Health Source Type: research