Development of the Gabriella Miller Kids First Pediatric Data Resource Center (U2C)
The objective of this FOA is to support the development of the Data Resource Center for the Gabriella Miller Kids First Pediatric Research Program (Kids First), which consists of the following components: a web-based Data Resource Portal, a Data Coordination Center, and Administrative and Outreach Core. The goal of the Data Resource Portal is to accelerate discovery of genetic etiology and shared biologic pathways within and across childhood cancers and structural birth defects by facilitating access to and querying of annotated genomic sequence and phenotypic data from cohorts of patients with these conditions. The Data Resource Portal will serve as an indispensable research resource where genomic data can be aggregated, accessed, analyzed, and shared within and across the childhood cancer and birth defects research communities as well as the broader scientific community. The Data Coordination Center will work with Kids First investigators and sequencing centers to facilitate data collection and harmonization. The Administrative and Outreach Core will oversee administrative activities, work closely with a Steering Committee, and provide outreach and education to the research community on using the Data Resource Portal.Version: Synopsis 1
Conclusion: Our data demonstrate that crocins could be a novel promising agent for the improvement of tumor treatment.
This article reviews the application of the precautionary principle during critical periods of growth and development and provides recommendations that may prevent epigenetic changes and reduce the risk for cancer. PMID: 31730600 [PubMed - in process]
ConclusionsThis is the first sun protection accreditation program developed for Spanish schools. Studies are needed to evaluate how this program is received and how it affects students’ sun protection behaviors.ResumenIntroducciónLa exposición solar en la infancia es el principal factor de riesgo para el desarrollo de cáncer de piel en la vida adulta. Las intervenciones basadas en programas y políticas de fotoprotección escolar han demostrado ser las estrategias más eficaces y coste-efectivas para la prevención del cáncer de piel.ObjetivosElaborar un modelo de c...
Teva Pharmaceuticals announced that it will resume production of childhood cancer drug vincristine after a recent shortage.
BOSTON (CBS) — Melanoma is the deadliest form of skin cancer, but a new study published in JAMA Dermatology finds melanoma rates are actually dropping, at least in young people. Melanoma is linked to exposing skin to ultraviolet light (UV), most notably through sunburns during childhood. Researchers looked at data from almost a million cases of invasive melanoma between 2006 and 2015, and found that while the rates ticked up in adults over 40, they dropped 23% among adolescents and adults under 30. They say this suggests that public health efforts to get people to use sun protection and avoid excessive UV exposure is working.
Conclusions: Collaborative efforts to conduct multi-centre trials are needed to further the field of paediatric oncology PT. PMID: 31719724 [PubMed]
Pharmaceutical company Teva USA announced today that it will resume production of childhood cancer drug vincristine after a recent shortage which led to patients missing doses of the vital chemotherapy.
More than 20 percent of those with family history of cancer had childhood asthma
(Children's Cancer Institute Australia) An Australian-led international research effort has broken fresh ground in the race to find more effective treatments for the childhood cancer neuroblastoma, by uncovering a new and as-yet unexploited target in cancer cells that therapeutic drugs can be aimed at.
E-cigarettes may be more harmful to a smoker’s heart than traditional tobacco cigarettes. That’s the finding of new research from Cedars-Sinai Medical Center in Los Angeles, presented today (Nov. 11) at an American Heart Association scientific conference. The Cedars-Sinai team compared the hearts of 10 non-smokers to the hearts of 10 tobacco smokers and 10 e-cigarette smokers. All the people in the study were younger than 40, and all were otherwise healthy. In response to a mild bout of exercise, measures of blood flow increased in the hearts of the non-smokers. Among the tobacco smokers, this increase was blun...