Excessive Iron and {alpha}-Synuclein Oligomer in Brain are Relevant to Pure Apathy in Parkinson Disease

Conclusion:
Patients with PD had high prevalence of pure apathy. Patients with PD having pure apathy had older age. Pure apathy reduced quality of life for patients without worsening motor function. Excessive iron and α-synuclein oligomer in brain commonly contributed to pure apathy of PD through potential mechanism of oxidative stress.

Source: Journal of Geriatric Psychiatry and Neurology - June 14, 2016 Category: Genetics & Stem Cells Authors: Wang, F., Yu, S.-Y., Zuo, L.-J., Cao, C.-J., Hu, Y., Chen, Z.-J., Piao, Y.-s., Wang, Y.-J., Wang, X.-M., Chen, S.-D., Chan, P., Zhang, W. Tags: Articles Source Type: research