Comparison of the combination of dexmedetomidine and ketamine to propofol or propofol/sevoflurane for drug‐induced sleep endoscopy in children

Summary AimExamination of dynamic airway collapse in patients with obstructive sleep apnea (OSA) during drug‐induced sleep endoscopy (DISE) can help identify the anatomic causes of airway obstruction. We hypothesized that a combination of dexmedetomidine and ketamine (Group DK) would result in fewer oxygen desaturations and a higher successful completion rate during DISE in children with OSA when compared to propofol (Group P) or sevoflurane/propofol (Group SP). MethodsIn this retrospective study, we reviewed the records of 59 children who presented for DISE between October 2013 and March 2015. Data analyzed included demographics, OSA severity, and hemodynamics (heart rate and blood pressure). The primary outcomes were airway desaturation during DISE to
Source: Pediatric Anesthesia - Category: Anesthesiology Authors: Tags: Research Report Source Type: research

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ConclusionsCompared with the general population, the prevalence of elevated CVP and OSA is significant in this cohort of patients. Age, diabetes, and right lower extremity chronic venous insufficiency symptoms seem to be predictors of elevated CVP. Larger, population-based prevalence studies are needed to confirm these findings.
Source: Journal of Vascular Surgery: Venous and Lymphatic Disorders - Category: Surgery Source Type: research
This study was a prospective, single cohort of consecutive adult patients undergoing MMA surgery for OSA at a single institution. The primary outcome measure was the development of nasal obstruction using the Nasal Obstruction Symptom Evaluation scale. Secondary outcomes included the rate of reintubation, submandibular duct function, development of neck infection, the need for subsequent surgical correction of nasal obstruction, and changes in the Apnea-Hypopnea Index.ResultsTwenty consecutive patients (85% male, mean age 47 years) were included in the study. Nasal Obstruction Symptom Evaluation scores improved in 88% of p...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Publication date: Available online 20 February 2020Source: The Annals of Thoracic SurgeryAuthor(s): Bhargavi Gali, Amy E. Glasgow, Kevin L. Greason, Rebecca L. Johnson, Robert C. Albright, Elizabeth B. HabermannAbstractBackgroundObstructive sleep apnea (OSA) is associated with increased risk of postoperative complications in non-cardiac surgery, with limited literature on cardiac surgical patients. We compared perioperative outcomes of patients with OSA to those without OSA undergoing cardiac surgery.MethodsThis was a retrospective single center cohort study of adult patients who underwent cardiac surgery from January 2010...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
ConclusionIn this study, we observed significant positive correlations between plasma vimentin level and OSA severity, weight, AHI, and mean oxygen desaturation. Vimentin may have utility as a biomarker in the follow-up and treatment of OSA.
Source: Lung - Category: Respiratory Medicine Source Type: research
Authors: Dzięciołowska-Baran E, Gawlikowska-Sroka A, Szczurowski J Abstract Polysomnography, a gold standard for the diagnosis of sleep-disordered breathing, is a complex investigation requiring access to the sleep laboratory. Thus, sleep-disordered breathing could be underdiagnosed. The aim of this paper was to investigate the feasibility and effectiveness of self-performed investigation of obstructive sleep apnea (OSA) in the home setting, using a portable device, and to assess the comfort and simplicity of the procedure from the patient's perspective. The study included 68 middle-aged patients (21 women and 47...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Publication date: Available online 20 February 2020Source: Journal of Evidence Based Dental PracticeAuthor(s): Kimberly Fluger, Alan Zhou, Thikriat Al-Jewair
Source: Journal of Evidence Based Dental Practice - Category: Dentistry Source Type: research
ConclusionsAnterior osteotomy just to the midline of inferior border and horizontal osteotomy to the mandibular foramen are associated with split patterns that result in optimal rigid fixation and passive bony overlap for OSA patients undergoing MMA.Clinical relevanceOptimal surgical technique has the most significant influence in allowing rapid return to function after MMA in patients with OSA.
Source: Clinical Oral Investigations - Category: Dentistry Source Type: research
The purpose of this study was to determine if submental intubation during maxillomandibular advancement (MMA) reduces the development of nasal obstruction in patients with obstructive sleep apnea (OSA).
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: Original Article Source Type: research
PMID: 32083949 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
Patients with previous acute coronary syndrome treated with CPAP for obstructive sleep apnea showed no significant reduction in subsequent cardiovascular events, in a randomized trial.Medscape Medical News
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Cardiology News Source Type: news
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