Prolyl hydroxylation regulates protein degradation, synthesis, and splicing in human induced pluripotent stem cell-derived cardiomyocytes

Conclusions
This study provides the first extensive characterization of the cardiac prolyl hydroxylome and demonstrates that inhibition of α-ketoglutarate hydroxylases alters protein stability, translation, and splicing.

Source: Cardiovascular Research - May 18, 2016 Category: Cardiology Authors: Stoehr, A., Yang, Y., Patel, S., Evangelista, A. M., Aponte, A., Wang, G., Liu, P., Boylston, J., Kloner, P. H., Lin, Y., Gucek, M., Zhu, J., Murphy, E. Tags: Cardiac biology and remodelling Source Type: research