Abstract B34: A novel role for {beta}-adrenergic receptor in mammary branching morphogenesis and its implication in breast cancer

In conclusion, β-AR stimulation seems to be involved in normal mammary development, leading to a terminal stage phenotype. In agreement with this, the analysis of a publicly available MicroArray dataset (GSE8191) showed an increase in β-AR expression levels during lactation. This study highlights a possible physiological role of β-AR in the development of mammary gland. Understanding the function of β-AR in normal development is crucial to elucidate its role in breast cancer and its possible use as a therapeutic target.Citation Format: Lucía Gargiulo, María May, Ezequiel Mariano Rivero, Lydon John, Caroline Lamb, Claudia Lanari, Isabel Alicia Luthy, Ariana Bruzzone. A novel role for β-adrenergic receptor in mammary branching morphogenesis and its implication in breast cancer. [abstract]. In: Proceedings of the AACR Special Conference: Developmental Biology and Cancer; Nov 30-Dec 3, 2015; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Res 2016;14(4_Suppl):Abstract nr B34.

Source: Molecular Cancer Research - May 2, 2016 Category: Cancer & Oncology Authors: May, M., Rivero, E. M., John, L., Lamb, C., Lanari, C., Luthy, I. A., Bruzzone, A. Tags: Other Topics: Poster Presentations - Proffered Abstracts Source Type: research