Immunohistochemical expression of DNA methyltransferases 1, 3a, and 3b in actinic cheilitis and lip squamous cell carcinomas

ConclusionsThe results suggested that DNMT 3a could play a key role in the methylation process of initial steps of UV carcinogenesis present in AC while DNMT 3b could be responsible for de novo methylation in already established lip cancer.

Source: Journal of Oral Pathology and Medicine - April 30, 2016 Category: Pathology Authors: Filipe I. Daniel, Soraia R. Alves, Daniella S. C. Vieira, Michelle T. Biz, Inah W. B. S. Daniel, Filipe Modolo Tags: Original Article Source Type: research