Folic Acid Supplementation in Postpolypectomy Patients in a Randomized Controlled Trial Increases Tissue Folate Concentrations and Reduces Aberrant DNA Biomarkers in Colonic Tissues Adjacent to the Former Polyp Site [Biochemical, Molecular, and Genetic Mechanisms]

Conclusion: A response to folic acid supplementation, which increased colonocyte folate and improved folate-related DNA biomarkers of cancer risk, was seen in the participants studied. Exploratory analysis points toward the area formerly adjacent to polyps as possibly driving the response. That these areas persist after polypectomy in the absence of folate supplementation is consistent with a potentially carcinogenic field’s causing the appearance of the polyp.

Source: Journal of Nutrition - May 1, 2016 Category: Nutrition Authors: OReilly, S. L., McGlynn, A. P., McNulty, H., Reynolds, J., Wasson, G. R., Molloy, A. M., Strain, J., Weir, D. G., Ward, M., McKerr, G., Scott, J. M., Downes, C. S. Tags: Biochemical, Molecular, and Genetic Mechanisms Source Type: research