Pyrazole antagonists of the CB1 receptor with reduced brain penetration - Fulp A, Zhang Y, Bortoff K, Seltzman H, Snyder R, Wiethe R, Amato G, Maitra R.

Type 1 cannabinoid receptor (CB1) antagonists might be useful for treating obesity, liver disease, metabolic syndrome, and dyslipidemias. Unfortunately, inhibition of CB1 in the central nervous system (CNS) produces adverse effects, including depression, a...
Source: SafetyLit - Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news