First-in-Human Phase I/II Study of NEOD001 in Patients With Light Chain Amyloidosis and Persistent Organ Dysfunction Clinical Trials

Conclusion Monthly infusions of NEOD001 were safe and well tolerated. Recommended future dosing was 24 mg/kg. Organ response rates compared favorably with those reported previously for chemotherapy. A phase II expansion is ongoing. A global phase III study (NCT02312206) has been initiated. Antibody therapy targeting misfolded proteins is a potential new therapy for the management of AL amyloidosis.
Source: Journal of Clinical Oncology - Category: Cancer & Oncology Authors: Tags: Phase I and Clinical Pharmacology Clinical Trials Source Type: research

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Conclusion: Inclusion of bronchial washings and endobronchial biopsies during bronchoscopy for chronic unexplained cough increased diagnostic yield from 28%, attributable to directly visualized anatomic etiologies, to 41%. The addition of microbiology cultures and pathology analysis significantly increased the diagnostic yield of bronchoscopy in identifying the potential etiology of chronic heretofore unexplained cough.
Source: Journal of Bronchology and Interventional Pulmonology - Category: Respiratory Medicine Tags: Original Investigations Source Type: research
In conclusion, in the absence of obesity, visceral adipose tissue possesses a pronounced anti-inflammatory phenotype during aging which is further enhanced by exercise. Methods of Inducing Cellular Damage are Rarely Relevant to Aging, and the Details Matter https://www.fightaging.org/archives/2019/08/methods-of-inducing-cellular-damage-are-rarely-relevant-to-aging-and-the-details-matter/ One of the major challenges in aging research is determining whether or not models of cellular or organismal damage and its consequences are in any way relevant to the natural processes of aging. One can hit a brick with...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
We reported a case of an 18-year-old woman presenting with dry cough and dyspnea on exertion for 6 months and detailed exams revealed multiple pulmonary nodules, positive antinuclear antibodies, hypocomplementemia, and thrombocytopenia. Diagnoses: A computed tomography-guided percutaneous lung biopsy revealed the histopathological features of pulmonary hyalinizing granuloma (PHG), but video-assisted pulmonary wedge resection for biopsy with immunohistochemical stains finally demonstrated a corrected diagnosis of intrapulmonary CD with secondary amyloidosis. Interventions: The patient had received prednisone and Tacro...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Rational: Clinical and radiologic manifestations of pleural amyloidosis are non-specific. And it can easily be missed or misdiagnosed. Meanwhile, few studies document amyloidosis presenting with pulmonary infarcts at the same time. Hereby, we report a case of immunoglobulin light chain amyloidosis (AL) pleural amyloidosis with pulmonary embolism rarely reported. Patient concerns: A 66-year-old male patient who suffered recurrent pleural effusion for more than 6 months and coughed for 2 months was admitted to hospital for clear diagnosis and treatment. He was previously engaged in a job which exposed him to dust and ta...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
A 61-year-old male patient was admitted to our hospital with complaints of chest pain and cough for a month. The patient had a history of ischemic heart disease and he worked in carpet washing factory. The patient had a coronary bypass history 3 years ago. Even though the patient does not smoke at the moment, he had 45 pack/years of cigarettes history. Bilateral respiratory voice sounds was coarse and expiration was long on physical examination of the patient. There was no feature in other system examinations. Requested Initial Laboratory Results during apply to a hospital are as follows;WBC:9,29 10e /u3L, Hgb:12,5g /dL, P...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
Publication date: Available online 26 February 2018 Source:Respiratory Medicine Case Reports Author(s): Amos Lal, Jamal Akhtar, Mohammad Saud Khan, Yayan Chen, Yaron Goldman Primary localized endobronchial amyloidosis is a rare entity, as pulmonary amyloidosis most commonly occurs as a part of systemic AL amyloidosis. It can be asymptomatic or can present with nonspecific symptoms such as progressive dyspnea, cough, wheezing and rarely respiratory failure. It is frequently misdiagnosed as asthma, COPD or pneumonia. Solitary endobronchial amyloidosis having a nodular appearance can mimic endobronchial tumor. The diagnosis ...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
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Source: Histopathology - Category: Pathology Authors: Tags: Lesson of the month Source Type: research
This 50-something with a history of alcohol abuse complained of 2 weeks of increasing dyspnea for 2 weeks, with some chest pain and cough. She was not ill-appearing.Her BP was 111/68, with a heart rate of 117, RR 22, Temp 36.4 C and SpO2 of 95%.She had a routine ECG performed at triage, as we do with all patients who are SOB.What do you think?I was brought this ECG and asked what I thought.I responded: there is very low voltage and tachycardia, does the ultrasound show an effusion?Here is the ED point of care ultrasound:There is a huge effusion with collapse of the RV. This is diagnostic of tamponade.A pigtail ca...
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
Conclusion This case report outlines the clinicopathological features that are characteristic of EHE with the hope of facilitating correct and early diagnosis in the future.
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Abstract: Pulmonary disorders are reported as rare extraintestinal manifestations of inflammatory bowel diseases. However, according to current literature, they are clinically underrecognized and likely underdiagnosed. While both parenchymal and airway lesions have been described, inflammatory bowel disease seems to preferentially affect the tracheobronchial tree, where it induces bronchiectasis, tracheobronchitis, and bronchitis. Respiratory involvement typically appears during a long-lasting disease, although symptoms of airway involvement may appear following surgery. Pathology features of tracheobronchitis have been do...
Source: Pathology Case Reviews - Category: Pathology Tags: Case Reports Source Type: research
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